Protein: PREP
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)

Gene: PREP, PITRM1
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q5JRX3

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006508 - proteolysis
GO:0006626 - protein targeting to mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1206215

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

1

High-throughput

0.611

High

1162356

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

142217

CCL22
C-C motif chemokine 22

2

4

High-throughput

0.574

High

1206244

TEKT3
Tektin-3

2

2

High-throughput

0.574

High

422267

A4
Amyloid-beta precursor protein

2

2

Small-scale

0.567

High

275304

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

2

High-throughput

0.536

High

1206220

FXL19
F-box/LRR-repeat protein 19

1

2

High-throughput

0.536

High

1206256

DIC
Mitochondrial dicarboxylate carrier

1

2

High-throughput

0.536

High

1206258

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

12

High-throughput

0.536

High

764219

CAH5A
Carbonic anhydrase 5A, mitochondrial

1

1

High-throughput

0.515

High

377826

IGF2
Insulin-like growth factor 2

1

3

High-throughput

0.514

High

1206226

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1206219

CGB2
Choriogonadotropin subunit beta variant 2

2

2

High-throughput

0.504

High

339769

KLF8
Krueppel-like factor 8

1

3

High-throughput

0.500

High

464982

SP1
Transcription factor Sp1

1

2

High-throughput

0.500

High

944675

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.500

High

1206232

SP7
Transcription factor Sp7

1

3

High-throughput

0.500

High

65468

PCARE
Photoreceptor cilium actin regulator

1

1

High-throughput

0.489

High

227232

KRT86
Keratin, type II cuticular Hb6

1

4

High-throughput

0.489

High

321722

DKK1
Dickkopf-related protein 1

1

1

High-throughput

0.489

High

354716

PAK4
Serine/threonine-protein kinase PAK 4

1

8

High-throughput

0.489

High

574049

HXB1
Homeobox protein Hox-B1

1

2

High-throughput

0.489

High

628581

ISK2
Serine protease inhibitor Kazal-type 2

1

3

High-throughput

0.489

High

724977

HXA7
Homeobox protein Hox-A7

1

2

High-throughput

0.489

High

1028997

TIAR
Nucleolysin TIAR

1

1

High-throughput

0.489

High

1030315

AMPD2
AMP deaminase 2

1

1

High-throughput

0.489

High

1127810

KRT81
Keratin, type II cuticular Hb1

1

4

High-throughput

0.489

High

1165363

ODAPH
Odontogenesis associated phosphoprotein

1

2

High-throughput

0.489

High

1198013

KR132
Keratin-associated protein 13-2

1

3

High-throughput

0.489

High

1206217

ISK14
Serine protease inhibitor Kazal-type 14

1

2

High-throughput

0.489

High

1206218

PRR27
Proline-rich protein 27

1

3

High-throughput

0.489

High

1206225

NAV3
Neuron navigator 3

1

1

High-throughput

0.489

High

1206260

CILK1
Serine/threonine-protein kinase ICK

1

2

High-throughput

0.489

High

143853

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

3

High-throughput

0.479

High

214257

LYRM1
LYR motif-containing protein 1

1

2

High-throughput

0.479

High

241899

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

279782

CISY
Citrate synthase, mitochondrial

1

6

High-throughput

0.479

High

283876

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

2

High-throughput

0.479

High

350888

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

4

High-throughput

0.479

High

471063

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

14

High-throughput

0.479

High

505436

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

4

High-throughput

0.479

High

1106936

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1200385

BOLA3
BolA-like protein 3

1

3

High-throughput

0.479

High

1206216

SDHF4
Succinate dehydrogenase assembly factor 4, mitochondrial

1

1

High-throughput

0.479

High

1206222

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1206224

NIT1
Deaminated glutathione amidase

1

3

High-throughput

0.479

High

1206229

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

3

High-throughput

0.479

High

1206234

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

5

High-throughput

0.479

High

1206236

COQ8B
Atypical kinase COQ8B, mitochondrial

1

9

High-throughput

0.479

High

1206238

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1206240

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

1206241

DHRS4
Dehydrogenase/reductase SDR family member 4

1

4

High-throughput

0.479

High

1206246

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

3

High-throughput

0.479

High

1206248

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

1206249

CQ10B
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

1

2

High-throughput

0.479

High

1206254

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

2

High-throughput

0.479

High

1206255

PAK5
Serine/threonine-protein kinase PAK 5

1

8

High-throughput

0.479

High

1206257

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1206262

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

5

High-throughput

0.479

High

213713

PAX4
Paired box protein Pax-4

1

1

High-throughput

0.470

High

361273

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

1013397

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1206235

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

240193

KLK8
Kallikrein-8

1

2

High-throughput

0.445

High

1103980

RM49
Large ribosomal subunit protein mL49

1

2

High-throughput

0.445

High

1206214

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1206239

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

1206253

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

1206261

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

8

High-throughput

0.445

High

125486

LEG9
Galectin-9

1

3

High-throughput

0.437

High

179520

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.437

High

588861

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

767060

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

3

High-throughput

0.437

High

830865

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

896547

VASP
Vasodilator-stimulated phosphoprotein

1

1

High-throughput

0.437

High

971601

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.437

High

1206231

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.437

High

1206243

DUS23
Dual specificity protein phosphatase 23

1

10

High-throughput

0.437

High

369183

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

261187

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330187

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

1206252

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

571449

GLU2B
Glucosidase 2 subunit beta

3

0

High-throughput

0.347

High

1206233

D104A
Beta-defensin 104

2

0

High-throughput

0.328

High

1206250

B2L12
Bcl-2-like protein 12

2

0

High-throughput

0.313

High

49940

LNP1
Leukemia NUP98 fusion partner 1

1

0

High-throughput

0.279

Low

165950

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

336594

PPN
Papilin

1

0

High-throughput

0.279

Low

1120533

NID2
Nidogen-2

1

0

High-throughput

0.279

Low

1139005

SNX17
Sorting nexin-17

1

0

High-throughput

0.279

Low

1186385

PKHG6
Pleckstrin homology domain-containing family G member 6

1

0

High-throughput

0.279

Low

1186826

KR196
Keratin-associated protein 19-6

1

0

High-throughput

0.279

Low

1206213

CI152
Uncharacterized protein C9orf152

1

0

High-throughput

0.279

Low

1206221

CEMP1
Cementoblastoma-derived protein 1

1

0

High-throughput

0.279

Low

1206223

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.279

Low

1206227

CF107
Cilia- and flagella-associated protein 107

1

0

High-throughput

0.279

Low

1206245

REG4
Regenerating islet-derived protein 4

1

0

High-throughput

0.279

Low

1206247

CFA68
Cilia- and flagella-associated protein 68

1

0

High-throughput

0.279

Low

1206251

AGO4
Protein argonaute-4

1

0

High-throughput

0.279

Low

686202

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.249

Low

964543

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.249

Low

1149898

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

1206228

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1206237

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1206230

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low

1206242

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.232

Low

1206259

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025