HitPredict

Interactor 1: IGHG1 (P01857)
Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Gene: IGHG1

Interactor 2: FCGR1 (P12314)
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Gene: FCGR1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	25925696
Identification Methods	x-ray crystallography, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~ig, C1-set~Ig_2, C1-set~Ig_3
Common GO terms	GO:0001788 - antibody-dependent cellular cytotoxicity GO:0005886 - plasma membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 374
+	Hs
		379219 IGHG1_HUMAN (1-399): 2.29e-108: 326: 100.00		FCG2B_HUMAN (101-287): 1.28e-28: 115: 16.58
+	Hs
		379285 IGHG1_HUMAN (1-399): 2.29e-108: 326: 100.00		TITIN_HUMAN (7-123): 4.74e-09: 60.5: 15.75
+	Hs
		1439198 ROBO1_HUMAN (4-267): 9e-23: 102: 13.86		ROBO2_HUMAN (3-374): 6.2e-67: 231: 16.13
+	Hs
		379171 IGHE_HUMAN (1-398): 8.4e-27: 113: 23.46		FCERA_HUMAN (98-317): 2.61e-38: 139: 20.81
+	Hs
		1491858 ROBO1_HUMAN (4-267): 9e-23: 102: 13.86		ROBO1_HUMAN (186-364): 1.14e-23: 105: 13.68
+	Hs
		1361879 TITIN_HUMAN (3-136): 9.12e-09: 60: 14.93		TITIN_HUMAN (7-123): 4.74e-09: 60.5: 15.75