HitPredict

Interactor 1: IGHG1 (P01857)
Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Gene: IGHG1

Interactor 2: FCG2B (P31994)
Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene: FCGR2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	11567028
Identification Methods	isothermal titration calorimetry, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~Ig_2
Common GO terms	GO:0001788 - antibody-dependent cellular cytotoxicity GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 310
+	Hs
		379203 IGHG1_HUMAN (1-399): 2.29e-108: 326: 100.00		FCGR1_HUMAN (5-282): 3.04e-23: 100: 12.29
+	Hs
		379285 IGHG1_HUMAN (1-399): 2.29e-108: 326: 100.00		TITIN_HUMAN (4-301): 1.41e-09: 61.3: 9.17
+	Hs
		1439198 ROBO1_HUMAN (4-267): 9e-23: 102: 13.86		ROBO2_HUMAN (3-294): 1.57e-41: 155: 14.68
+	Dr
		72641 B0CLV6_DANRE (106-343): 1.42e-17: 85.8: 14.63		Q6PFK4_DANRE (5-244): 8.38e-46: 161: 18.89
+	Hs
		1491858 ROBO1_HUMAN (4-267): 9e-23: 102: 13.86		ROBO1_HUMAN (127-306): 5.04e-22: 98.7: 11.62
+	Hs
		379171 IGHE_HUMAN (1-398): 8.4e-27: 113: 23.46		FCERA_HUMAN (2-133): 1.01e-11: 66: 16.06
+	Rn
		236995 ROBO1_RAT (4-229): 1.28e-22: 102: 13.97		DCC_RAT (2-280): 4.48e-10: 62.5: 11.18
+	Hs
		1361879 TITIN_HUMAN (3-136): 9.12e-09: 60: 14.93		TITIN_HUMAN (4-301): 1.41e-09: 61.3: 9.17