HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: SIR3 (P06701)
Regulatory protein SIR3 (Silent information regulator 3)
Gene: SIR3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.80	0.812

Property	Details
Experiments	8779721, 18158899, 19217406, 37968396, 21179020
Identification Methods	coimmunoprecipitation, experimental interaction detection, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BAH~Histone
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 131 Sc			1 978
+	Sc
		381356 H2B2_YEAST (1-131): 1.47e-45: 146: 96.95		SIR3_YEAST (1-978): 0: 937: 100.00
+	Sc
		381590 H2B2_YEAST (1-131): 1.47e-45: 146: 96.95		ORC1_YEAST (1-975): 0: 754: 23.77
+	Sc
		381205 H2B1_YEAST (1-131): 2.55e-44: 143: 100.00		ORC1_YEAST (1-975): 0: 754: 23.77
+	Hs
		1104314 H2B2E_HUMAN (7-128): 3.7e-46: 147: 70.97		ORC1_HUMAN (179-959): 3.68e-175: 533: 13.85
+	Hs
		231487 H2B2E_HUMAN (7-128): 3.7e-46: 147: 70.97		ORC4_HUMAN (534-893): 9.54e-53: 192: 11.37
+	Hs
		770006 H2B2E_HUMAN (7-128): 3.7e-46: 147: 70.97		RFC1_HUMAN (129-771): 6.82e-26: 117: 12.24
+	Hs
		754742 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		RFC1_HUMAN (129-771): 6.82e-26: 117: 12.24
+	Hs
		769963 H2B1C_HUMAN (7-128): 6.83e-46: 146: 70.97		RFC1_HUMAN (129-771): 6.82e-26: 117: 12.24
+	Sc
		381593 H2B2_YEAST (1-131): 1.47e-45: 146: 96.95		ORC4_YEAST (490-896): 8.66e-16: 83.5: 8.37
+	Sc
		381207 H2B1_YEAST (1-131): 2.55e-44: 143: 100.00		ORC4_YEAST (490-896): 8.66e-16: 83.5: 8.37
+	Sc
		381506 H2B2_YEAST (1-131): 1.47e-45: 146: 96.95		RFC1_YEAST (265-769): 2.55e-14: 79.7: 10.46
+	Sc
		381090 H2B1_YEAST (1-131): 2.55e-44: 143: 100.00		RFC1_YEAST (265-769): 2.55e-14: 79.7: 10.46