Protein: ORC1
Origin recognition complex subunit 1 (Replication control protein 1)

Gene: ORC1
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q13415

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000808 - origin recognition complex
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104303

ORC2
Origin recognition complex subunit 2

12

13

Small-scale

0.981

High

230899

ORC5
Origin recognition complex subunit 5

8

19

Small-scale

0.969

High

1104333

ORC3
Origin recognition complex subunit 3

7

13

Small-scale

0.965

High

231473

ORC4
Origin recognition complex subunit 4

6

13

Small-scale

0.942

High

1104326

CDC6
Cell division control protein 6 homolog

3

15

Small-scale

0.882

High

979604

H4
Histone H4

3

7

Small-scale

0.814

High

1104314

H2B2E
Histone H2B type 2-E

2

7

Small-scale

0.789

High

629116

CCNA2
Cyclin-A2

6

7

Small-scale

0.736

High

829205

RFC3
Replication factor C subunit 3

1

7

High-throughput

0.691

High

1104321

PHIP
PH-interacting protein

1

2

High-throughput

0.691

High

1104322

PHF3
PHD finger protein 3

1

2

High-throughput

0.691

High

1104310

TERF2
Telomeric repeat-binding factor 2

3

1

Small-scale

0.672

High

1104309

ELOB
Elongin-B

1

0

High-throughput

0.656

High

667825

CDK2
Cyclin-dependent kinase 2

2

12

Small-scale

0.639

High

1101802

SKP2
S-phase kinase-associated protein 2

2

1

Small-scale

0.634

High

507187

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

15

Small-scale

0.618

High

1104302

ORC1
Origin recognition complex subunit 1

1

16

Small-scale

0.618

High

1104313

H2A2C
Histone H2A type 2-C

1

5

Small-scale

0.618

High

1104335

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

2

Small-scale

0.611

High

371947

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

559338

XRCC5
X-ray repair cross-complementing protein 5

2

5

Small-scale

0.584

High

442697

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.578

High

332000

KAT7
Histone acetyltransferase KAT7

1

3

Small-scale

0.573

High

396047

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

1104317

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

1

Small-scale

0.561

High

65038

GG6L9
Golgin subfamily A member 6-like protein 9

2

4

High-throughput

0.553

High

755903

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.536

High

1104325

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1104328

CDT1
DNA replication factor Cdt1

1

2

High-throughput

0.536

High

303541

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

391245

FRIL
Ferritin light chain

1

2

High-throughput

0.536

High

884634

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

995018

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

1089194

TRI26
Tripartite motif-containing protein 26

1

1

High-throughput

0.536

High

1104315

LARP7
La-related protein 7

1

3

High-throughput

0.536

High

1104318

CHM1B
Charged multivesicular body protein 1b

1

1

High-throughput

0.536

High

1104319

PHF6
PHD finger protein 6

1

1

High-throughput

0.536

High

1104331

DPOE3
DNA polymerase epsilon subunit 3

1

2

High-throughput

0.536

High

1012311

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.513

High

1104306

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

1104307

CIRBP
Cold-inducible RNA-binding protein

1

0

High-throughput

0.513

High

1104311

ZN174
Zinc finger protein 174

1

0

High-throughput

0.513

High

1104320

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.513

High

1104336

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.513

High

853247

CBX5
Chromobox protein homolog 5

1

3

Small-scale

0.501

High

165576

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.489

High

630268

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

6

High-throughput

0.489

High

1104338

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.489

High

132471

CDC7
Cell division cycle 7-related protein kinase

1

7

Small-scale

0.481

High

588614

RFA2
Replication protein A 32 kDa subunit

1

2

Small-scale

0.481

High

755701

MCM4
DNA replication licensing factor MCM4

1

20

Small-scale

0.481

High

756176

MCM7
DNA replication licensing factor MCM7

1

20

Small-scale

0.481

High

888033

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.481

High

1104308

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.481

High

1104334

DBF4A
Protein DBF4 homolog A

1

1

Small-scale

0.481

High

601657

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.480

High

362278

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

413769

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

440540

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

443347

CDK1
Cyclin-dependent kinase 1

1

12

Small-scale

0.479

High

558101

XRCC6
X-ray repair cross-complementing protein 6

1

5

Small-scale

0.479

High

910492

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

Small-scale

0.479

High

956658

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

1

Small-scale

0.479

High

960415

PSME3
Proteasome activator complex subunit 3

1

2

Small-scale

0.479

High

992161

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.479

High

1045247

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1104304

CUL1
Cullin-1

1

3

Small-scale

0.479

High

1104305

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1104312

NFIL3
Nuclear factor interleukin-3-regulated protein

1

1

Small-scale

0.479

High

1104323

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1104324

CCNL2
Cyclin-L2

1

4

Small-scale

0.479

High

1104329

ZN768
Zinc finger protein 768

1

1

High-throughput

0.479

High

281204

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.460

High

223006

PRC1
Protein regulator of cytokinesis 1

1

0

Small-scale

0.458

High

596879

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

1023053

RBM10
RNA-binding protein 10

1

0

Small-scale

0.458

High

1104316

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.458

High

1104332

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

116329

H3BS42
Zinc finger protein 768

1

1

High-throughput

0.445

High

1007635

CCNA1
Cyclin-A1

1

7

Small-scale

0.445

High

1063228

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.439

High

1104327

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

58813

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.407

High

162192

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.279

Low

1104330

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.279

Low

1104337

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025