Protein: SIR3
Regulatory protein SIR3 (Silent information regulator 3)

Gene: SIR3
Organism: Saccharomyces cerevisiae S288C
Interactions: 83
UniProt ID: P06701

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003676 - nucleic acid binding
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444810

SIR3
Regulatory protein SIR3

10

15

Small-scale

0.978

High

381784

H4
Histone H4

15

8

Small-scale

0.882

High

444866

H3
Histone H3

15

9

Small-scale

0.881

High

444828

SIR1
Regulatory protein SIR1

3

1

Small-scale

0.860

High

419319

H2A1
Histone H2A.1

3

7

Small-scale

0.839

High

419544

H2A2
Histone H2A.2

3

7

Small-scale

0.817

High

380915

H2B1
Histone H2B.1

5

12

Small-scale

0.812

High

444723

SIR2
NAD-dependent histone deacetylase SIR2

8

1

Small-scale

0.749

High

444821

SIR4
Regulatory protein SIR4

22

0

Small-scale

0.734

High

381356

H2B2
Histone H2B.2

3

12

Small-scale

0.731

High

444820

RAP1
DNA-binding protein RAP1

8

0

Small-scale

0.726

High

444868

SLT2
Mitogen-activated protein kinase SLT2/MPK1

2

2

Small-scale

0.619

High

444857

COM1
DNA endonuclease SAE2

2

0

Small-scale

0.613

High

444834

MCM10
Minichromosome maintenance protein 10

2

5

Small-scale

0.595

High

444835

ASF2
Anti-silencing protein 2

2

1

Small-scale

0.584

High

444843

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.575

High

444847

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.553

High

444829

SNF2
Transcription regulatory protein SNF2

1

5

Small-scale

0.536

High

439058

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

1

High-throughput

0.536

High

444817

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.536

High

444871

RUVB1
RuvB-like protein 1

2

3

High-throughput

0.521

High

444872

HMO1
High mobility group protein 1

1

7

High-throughput

0.515

High

444813

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.513

High

444830

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

High-throughput

0.513

High

444839

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.513

High

444846

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.513

High

444863

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

Small-scale

0.501

High

366873

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.500

High

444812

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.500

High

444823

HSP26
Heat shock protein 26

1

6

High-throughput

0.500

High

444815

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

1

High-throughput

0.489

High

444819

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.489

High

444859

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.489

High

444875

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

1

High-throughput

0.489

High

444849

ATM
Serine/threonine-protein kinase TEL1

1

4

Small-scale

0.481

High

444850

RT107
Regulator of Ty1 transposition protein 107

1

1

Small-scale

0.481

High

444860

ZDS1
Protein ZDS1

1

2

Small-scale

0.481

High

367348

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.479

High

444825

HXKG
Glucokinase-1

1

0

High-throughput

0.479

High

444844

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

444845

BDF1
Bromodomain-containing factor 1

1

8

High-throughput

0.479

High

444854

RT106
Histone chaperone RTT106

1

1

Small-scale

0.479

High

444864

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

444873

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

444879

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

444824

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.470

High

444877

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

1

High-throughput

0.470

High

444865

ZDS2
Protein ZDS2

1

2

Small-scale

0.464

High

444827

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

444856

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

444870

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.458

High

444876

ARP9
Actin-like protein ARP9

1

3

Small-scale

0.457

High

444818

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.457

High

444826

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.457

High

444831

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.457

High

444822

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

444837

ZUO1
Zuotin

1

4

High-throughput

0.445

High

444851

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.445

High

444862

H1
Histone H1

1

1

High-throughput

0.445

High

444867

CDC14
Tyrosine-protein phosphatase CDC14

1

5

High-throughput

0.445

High

444869

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

6

High-throughput

0.445

High

444833

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

444838

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.437

High

444878

SGO1
Shugoshin

1

1

High-throughput

0.437

High

444858

NET1
Nucleolar protein NET1

1

0

High-throughput

0.426

High

444816

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

444840

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.407

High

444841

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

1

High-throughput

0.407

High

444848

LHS1
Heat shock protein 70 homolog LHS1

1

10

High-throughput

0.407

High

444852

CAJ1
Protein CAJ1

1

3

High-throughput

0.407

High

444880

HSP42
Heat shock protein 42

1

6

High-throughput

0.407

High

444881

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.407

High

444811

RAD7
DNA repair protein RAD7

3

0

Small-scale

0.351

High

444814

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

444853

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.279

Low

444874

ADH6
NADP-dependent alcohol dehydrogenase 6

1

0

High-throughput

0.279

Low

444861

RMR1
Reduced meiotic recombination protein 1

1

0

High-throughput

0.265

Low

444842

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low

444855

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

367462

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.249

Low

444836

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

444832

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025