Protein: RFC1
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)

Gene: RFC1
Organism: Homo sapiens
Interactions: 214
UniProt ID: P35251

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003689 - DNA clamp loader activity
GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550890

PCNA
Proliferating cell nuclear antigen

13

15

Small-scale

0.980

High

769667

RFC4
Replication factor C subunit 4

5

17

Small-scale

0.919

High

259533

BRD4
Bromodomain-containing protein 4

4

20

Small-scale

0.893

High

769933

RFC5
Replication factor C subunit 5

4

20

Small-scale

0.887

High

769934

RFC3
Replication factor C subunit 3

3

20

Small-scale

0.853

High

769815

RFC2
Replication factor C subunit 2

3

17

Small-scale

0.817

High

507603

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

High-throughput

0.778

High

240901

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.754

High

557897

XRCC6
X-ray repair cross-complementing protein 6

2

9

High-throughput

0.754

High

769931

BRCA1
Breast cancer type 1 susceptibility protein

2

4

Small-scale

0.737

High

487018

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.691

High

769940

NOTC1
Neurogenic locus notch homolog protein 1

1

4

High-throughput

0.691

High

770069

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.691

High

769968

H31
Histone H3.1

4

20

High-throughput

0.676

High

770074

HECD1
E3 ubiquitin-protein ligase HECTD1

2

8

Small-scale

0.675

High

767538

RFA3
Replication protein A 14 kDa subunit

3

7

High-throughput

0.656

High

371319

MYC
Myc proto-oncogene protein

3

6

High-throughput

0.640

High

694757

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

8

Small-scale

0.640

High

770072

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.631

High

446705

NPM
Nucleophosmin

2

3

High-throughput

0.628

High

769978

TF65
Transcription factor p65

2

7

Small-scale

0.624

High

769973

ANK2
Ankyrin-2

1

1

High-throughput

0.618

High

298579

RAD17
Cell cycle checkpoint protein RAD17

1

19

Small-scale

0.618

High

559243

XRCC5
X-ray repair cross-complementing protein 5

1

9

Small-scale

0.618

High

674093

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.618

High

769999

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.618

High

770030

TOPB1
DNA topoisomerase 2-binding protein 1

1

9

High-throughput

0.618

High

770059

BRD7
Bromodomain-containing protein 7

1

9

High-throughput

0.618

High

770065

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.618

High

208188

RRP8
Ribosomal RNA-processing protein 8

2

0

High-throughput

0.602

High

536617

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

588043

RFA2
Replication protein A 32 kDa subunit

2

9

High-throughput

0.584

High

664654

CCND1
G1/S-specific cyclin-D1

2

3

Small-scale

0.584

High

769961

RS6
Small ribosomal subunit protein eS6

2

5

High-throughput

0.584

High

769962

H4
Histone H4

2

10

High-throughput

0.584

High

769963

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

770051

SPRTN
DNA-dependent metalloprotease SPRTN

2

4

Small-scale

0.584

High

770056

WDR76
WD repeat-containing protein 76

2

14

High-throughput

0.584

High

770061

ANLN
Anillin

2

4

High-throughput

0.584

High

769988

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.561

High

643704

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.559

High

769949

TSP3
Thrombospondin-3

2

3

High-throughput

0.558

High

262028

NBN
Nibrin

1

0

Small-scale

0.546

High

770022

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.541

High

74442

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.536

High

140774

NOP56
Nucleolar protein 56

1

4

High-throughput

0.536

High

191548

MAGB2
Melanoma-associated antigen B2

1

4

High-throughput

0.536

High

286884

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

3

High-throughput

0.536

High

290465

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

328637

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

501926

H2AZ
Histone H2A.Z

1

7

High-throughput

0.536

High

521564

H14
Histone H1.4

1

2

High-throughput

0.536

High

541861

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

769941

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

769952

HDGF
Hepatoma-derived growth factor

1

6

High-throughput

0.536

High

769959

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.536

High

769972

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.536

High

769979

FAK1
Focal adhesion kinase 1

1

6

High-throughput

0.536

High

769980

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.536

High

769990

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.536

High

770006

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

770019

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

2

High-throughput

0.536

High

770023

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.536

High

770029

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

770053

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

770054

SENP3
Sentrin-specific protease 3

1

4

High-throughput

0.536

High

770067

H2AW
Core histone macro-H2A.2

1

9

High-throughput

0.536

High

770070

DAXX
Death domain-associated protein 6

1

2

High-throughput

0.536

High

770076

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

3

High-throughput

0.536

High

770040

DDRGK
DDRGK domain-containing protein 1

2

4

Small-scale

0.533

High

770049

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.518

High

769995

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

Small-scale

0.515

High

225541

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

567274

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

685996

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

769945

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.513

High

770001

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

770039

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

770042

ZN668
Zinc finger protein 668

1

0

High-throughput

0.513

High

770043

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

769967

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

690779

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

770034

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

770021

OXR1
Oxidation resistance protein 1

1

0

High-throughput

0.493

High

769947

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.489

High

769997

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.489

High

770079

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

128809

MEN1
Menin

1

4

High-throughput

0.479

High

131768

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

190833

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

7

High-throughput

0.479

High

315203

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

334514

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.479

High

385506

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

395596

ESR1
Estrogen receptor

1

15

High-throughput

0.479

High

400386

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

403871

GCR
Glucocorticoid receptor

1

15

High-throughput

0.479

High

411470

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

413303

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

418863

H2A1B
Histone H2A type 1-B/E

1

8

High-throughput

0.479

High

442616

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

472483

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.479

High

606328

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

620163

NUCL
Nucleolin

1

2

High-throughput

0.479

High

629600

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

697019

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

754742

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

769935

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

769936

ETV3
ETS translocation variant 3

1

3

High-throughput

0.479

High

769938

NKX21
Homeobox protein Nkx-2.1

1

6

High-throughput

0.479

High

769939

ATRX
Transcriptional regulator ATRX

1

11

Small-scale

0.479

High

769942

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.479

High

769943

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

769944

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

769946

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

769951

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

769955

PMS1
PMS1 protein homolog 1

1

6

High-throughput

0.479

High

769958

RS7
Small ribosomal subunit protein eS7

1

4

High-throughput

0.479

High

769960

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

769964

RL31
Large ribosomal subunit protein eL31

1

5

High-throughput

0.479

High

769965

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

769969

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

769970

H33
Histone H3.3

1

20

High-throughput

0.479

High

769971

VIGLN
Vigilin

1

4

High-throughput

0.479

High

769975

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

769977

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

769981

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.479

High

769983

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

769984

SKP2
S-phase kinase-associated protein 2

1

5

Small-scale

0.479

High

769986

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

769987

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

769989

CUL1
Cullin-1

1

5

Small-scale

0.479

High

769991

TRI29
Tripartite motif-containing protein 29

1

5

Small-scale

0.479

High

769996

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

769998

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

770000

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

770002

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

770003

E2F4
Transcription factor E2F4

1

6

High-throughput

0.479

High

770004

FSCN1
Fascin

1

1

High-throughput

0.479

High

770005

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

770013

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

770014

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

770016

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

770020

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

770024

NUP43
Nucleoporin Nup43

1

14

High-throughput

0.479

High

770028

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

770031

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

770035

LHX4
LIM/homeobox protein Lhx4

1

4

High-throughput

0.479

High

770036

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

770037

Q96BE0
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

770038

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

770044

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

770045

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

770047

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

770048

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

4

Small-scale

0.479

High

770050

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.479

High

770058

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

770060

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

770062

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

770064

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

770066

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

770068

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

770071

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

770075

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

770077

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

770078

MAFB
Transcription factor MafB

1

9

High-throughput

0.479

High

770046

MYOC
Myocilin

1

0

Small-scale

0.460

High

171840

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

194017

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

408702

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

549076

CDK4
Cyclin-dependent kinase 4

1

0

Small-scale

0.458

High

767109

MERL
Merlin

1

0

High-throughput

0.458

High

769982

REST
RE1-silencing transcription factor

1

0

High-throughput

0.458

High

770012

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.458

High

770026

CTCFL
Transcriptional repressor CTCFL

1

0

High-throughput

0.458

High

770027

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

770073

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

429402

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

769932

MLH1
DNA mismatch repair protein Mlh1

1

6

Small-scale

0.445

High

769937

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.445

High

769953

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.445

High

769954

BLM
RecQ-like DNA helicase BLM

1

5

Small-scale

0.445

High

769966

YBOX1
Y-box-binding protein 1

1

4

High-throughput

0.445

High

769974

XPC
DNA repair protein complementing XP-C cells

1

1

High-throughput

0.445

High

769985

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.445

High

770007

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

770017

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

770025

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

2

High-throughput

0.445

High

770032

ESR2
Estrogen receptor beta

1

15

High-throughput

0.445

High

770033

RAD50
DNA repair protein RAD50

1

8

Small-scale

0.445

High

770057

LN28A
Protein lin-28 homolog A

1

4

High-throughput

0.445

High

271942

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

769993

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.437

High

770008

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

770009

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

770055

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

769950

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.426

High

770041

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.426

High

770063

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.426

High

769948

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

188093

MOT6
Monocarboxylate transporter 6

1

1

High-throughput

0.407

High

769956

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.407

High

770015

SO6A1
Solute carrier organic anion transporter family member 6A1

1

1

High-throughput

0.407

High

546965

FGF3
Fibroblast growth factor 3

1

0

High-throughput

0.279

Low

769957

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.279

Low

769976

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.279

Low

769994

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

359936

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.249

Low

769992

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

770010

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

770018

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

62460

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

190320

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

770011

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

770052

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025