HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: LIRB1 (Q8NHL6)
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
Gene: LILRB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	12897781, 24018270
Identification Methods	x-ray crystallography, surface plasmon resonance
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	C1-set~ig, C1-set~Ig_2, MHC_I~ig
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0032729 - positive regulation of type II interferon production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Hs			1 650
+	Hs
		1245576 Q95J06_HUMAN (1-365): 0: 508: 92.33		LIRB1_HUMAN (1-650): 2.42e-147: 443: 100.00
+	Hs
		1130838 Q5S3G3_HUMAN (1-365): 3.89e-177: 498: 98.08		LIRB1_HUMAN (1-650): 2.42e-147: 443: 100.00
+	Hs
		1232786 Q95J06_HUMAN (1-365): 0: 508: 92.33		LIRB2_HUMAN (1-650): 2.34e-117: 364: 76.31
+	Hs
		382478 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		LIRB2_HUMAN (1-650): 2.34e-117: 364: 76.31
+	Hs
		1130837 Q5S3G3_HUMAN (1-365): 3.89e-177: 498: 98.08		LIRB2_HUMAN (1-650): 2.34e-117: 364: 76.31
+	Hs
		1060406 Q95J06_HUMAN (1-365): 0: 508: 92.33		KI3S1_HUMAN (1-334): 4.36e-69: 231: 35.91
+	Hs
		382420 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		KI3S1_HUMAN (1-334): 4.36e-69: 231: 35.91
+	Hs
		1060403 Q5SUL5_HUMAN (1-365): 2.46e-175: 493: 95.89		KI3S1_HUMAN (1-334): 4.36e-69: 231: 35.91
+	Hs
		382341 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		KI3L2_HUMAN (1-334): 1.36e-63: 219: 35.91
+	Hs
		798244 Q5S3G3_HUMAN (1-365): 3.89e-177: 498: 98.08		KI3L2_HUMAN (1-334): 1.36e-63: 219: 35.91
+	Hs
		798280 Q5S3G3_HUMAN (1-365): 3.89e-177: 498: 98.08		KI2S4_HUMAN (120-337): 1.27e-52: 185: 38.36
+	Hs
		798195 Q5S3G3_HUMAN (1-365): 3.89e-177: 498: 98.08		KI2L3_HUMAN (319-581): 5.31e-33: 131: 22.92
+	Hs
		382484 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		LIRB4_HUMAN (119-586): 1.76e-29: 124: 19.83
+	Hs
		798194 Q5RIP0_HUMAN (1-364): 4.84e-164: 464: 83.29		KI2L3_HUMAN (319-581): 5.31e-33: 131: 22.92
+	Hs
		798190 Q5D1W8_HUMAN (1-364): 2.27e-162: 460: 82.74		KI2L3_HUMAN (319-581): 5.31e-33: 131: 22.92
+	Hs
		798173 Q5RIP0_HUMAN (1-364): 4.84e-164: 464: 83.29		KI2L2_HUMAN (319-581): 4.84e-31: 126: 22.33
+	Hs
		47499 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		A0A8I5QEB2_HUMAN (319-536): 2.04e-18: 90.1: 21.88
+	Hs
		798148 Q5RIP0_HUMAN (1-364): 4.84e-164: 464: 83.29		KI2L1_HUMAN (319-581): 8.17e-30: 122: 20.33
+	Hs
		798171 Q5D1W8_HUMAN (1-364): 2.27e-162: 460: 82.74		KI2L2_HUMAN (319-581): 4.84e-31: 126: 22.33
+	Hs
		798146 Q5D1W8_HUMAN (1-364): 2.27e-162: 460: 82.74		KI2L1_HUMAN (319-581): 8.17e-30: 122: 20.33