HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Method score

Annotation score

Interaction score

0.93

1.00

0.965

Property	Details
Experiments	19285555, 19931242, 18160478, 18042364, 17914904, 19826086, 20541508
Identification Methods	comigration in sds page, cross-linking study, enzyme linked immunosorbent assay, fluorescent resonance energy transfer, circular dichroism, force spectroscopy, x-ray crystallography, cosedimentation in solution
Interaction Type	direct interaction, physical association, association, covalent binding

Property

Details

Experiments

19285555, 19931242, 18160478, 18042364, 17914904, 19826086, 20541508

Identification Methods

comigration in sds page, cross-linking study, enzyme linked immunosorbent assay, fluorescent resonance energy transfer, circular dichroism, force spectroscopy, x-ray crystallography, cosedimentation in solution

Interaction Type

direct interaction, physical association, association, covalent binding

Property	Details
Interacting Pfam domains	fn1~fn1, fn1~fn2, fn2~fn2, fn3~fn3
Common GO terms	GO:0001525 - angiogenesis GO:0001932 - regulation of protein phosphorylation GO:0002020 - protease binding GO:0005102 - signaling receptor binding GO:0005178 - integrin binding and 46 others more... GO:0005201 - extracellular matrix structural constituent GO:0005518 - collagen binding GO:0005576 - extracellular region GO:0005577 - fibrinogen complex GO:0005604 - basement membrane GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment GO:0005886 - plasma membrane GO:0006953 - acute-phase response GO:0007044 - cell-substrate junction assembly GO:0007155 - cell adhesion GO:0007160 - cell-matrix adhesion GO:0007161 - calcium-independent cell-matrix adhesion GO:0007229 - integrin-mediated signaling pathway GO:0007399 - nervous system development GO:0007507 - heart development GO:0008201 - heparin binding GO:0008284 - positive regulation of cell population proliferation GO:0008360 - regulation of cell shape GO:0009611 - response to wounding GO:0010628 - positive regulation of gene expression GO:0014850 - response to muscle activity GO:0016324 - apical plasma membrane GO:0016504 - peptidase activator activity GO:0018149 - peptide cross-linking GO:0031012 - extracellular matrix GO:0031093 - platelet alpha granule lumen GO:0033622 - integrin activation GO:0034446 - substrate adhesion-dependent cell spreading GO:0035987 - endodermal cell differentiation GO:0042060 - wound healing GO:0043394 - proteoglycan binding GO:0043542 - endothelial cell migration GO:0045773 - positive regulation of axon extension GO:0048018 - receptor ligand activity GO:0048146 - positive regulation of fibroblast proliferation GO:0051702 - biological process involved in interaction with symbiont GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0070062 - extracellular exosome GO:0070372 - regulation of ERK1 and ERK2 cascade GO:0071635 - negative regulation of transforming growth factor beta production GO:0072562 - blood microparticle GO:0150102 - negative regulation of monocyte activation GO:1901166 - neural crest cell migration involved in autonomic nervous system development GO:1904237 - positive regulation of substrate-dependent cell migration, cell attachment to substrate
Homologous interactions	18