Protein: MMP9
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]

Gene: MMP9
Organism: Homo sapiens
Interactions: 64
UniProt ID: P14780

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001934 - positive regulation of protein phosphorylation
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0004252 - serine-type endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369998

TIMP1
Metalloproteinase inhibitor 1

4

20

Small-scale

0.892

High

575770

MMP9
Matrix metalloproteinase-9

3

9

Small-scale

0.853

High

388984

FINC
Fibronectin

2

12

High-throughput

0.811

High

565085

CSPG2
Versican core protein

1

18

Small-scale

0.724

High

575795

COL12
Collectin-12

1

20

High-throughput

0.691

High

575784

NGAL
Neutrophil gelatinase-associated lipocalin

4

3

Small-scale

0.676

High

575781

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

3

20

Small-scale

0.670

High

384239

CO2A1
Collagen alpha-1(II) chain

2

20

High-throughput

0.628

High

384300

CO4A1

2

20

High-throughput

0.628

High

471579

CO4A2

2

20

High-throughput

0.628

High

551753

CO6A1

2

18

High-throughput

0.628

High

551835

CO6A2

2

20

High-throughput

0.628

High

575778

CO5A1

2

20

High-throughput

0.628

High

575787

COEA1
Collagen alpha-1(XIV) chain

2

20

High-throughput

0.628

High

575802

COCA1

2

20

High-throughput

0.628

High

575783

CXCL6
C-X-C motif chemokine 6

2

20

Small-scale

0.585

High

575785

TF65
Transcription factor p65

2

2

Small-scale

0.584

High

575792

BGH3
Transforming growth factor-beta-induced protein ig-h3

1

2

Small-scale

0.578

High

575772

TIMP2
Metalloproteinase inhibitor 2

1

20

Small-scale

0.575

High

575779

SFTPD
Pulmonary surfactant-associated protein D

1

20

Small-scale

0.575

High

575796

SCAR3
Scavenger receptor class A member 3

2

20

High-throughput

0.574

High

431684

ITB1
Integrin beta-1

2

10

Small-scale

0.571

High

518756

IL8
Interleukin-8

2

20

Small-scale

0.552

High

210698

KLK10
Kallikrein-10

1

13

High-throughput

0.536

High

473649

ITA5
Integrin alpha-5

1

8

Small-scale

0.536

High

575786

GLGB
1,4-alpha-glucan-branching enzyme

1

2

High-throughput

0.536

High

575800

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.536

High

575803

EGFL8
Epidermal growth factor-like protein 8

1

12

High-throughput

0.536

High

376696

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

5

Small-scale

0.501

High

465931

CO1A2
Collagen alpha-2(I) chain

1

20

Small-scale

0.501

High

575782

CXCL5
C-X-C motif chemokine 5

1

20

Small-scale

0.501

High

575807

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

575793

MEP1A
Meprin A subunit alpha

1

5

Small-scale

0.484

High

575794

MEP1B
Meprin A subunit beta

1

5

Small-scale

0.484

High

518649

SRGN
Serglycin

1

0

Small-scale

0.480

High

127269

LEG8
Galectin-8

1

16

Small-scale

0.479

High

460763

CATB
Cathepsin B

1

2

Small-scale

0.479

High

464412

TSP1
Thrombospondin-1

1

8

Small-scale

0.479

High

464783

SP1
Transcription factor Sp1

1

1

Small-scale

0.479

High

533575

CLUS
Clusterin

1

3

Small-scale

0.479

High

575776

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

Small-scale

0.479

High

575780

TSP2
Thrombospondin-2

1

9

Small-scale

0.479

High

575788

EP300
Histone acetyltransferase p300

1

4

Small-scale

0.479

High

575797

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

5

Small-scale

0.479

High

575801

CBP
CREB-binding protein

1

4

Small-scale

0.479

High

575805

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

533866

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

575775

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

575789

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

Small-scale

0.458

High

575791

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

575806

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.458

High

469406

ELNE
Neutrophil elastase

1

12

Small-scale

0.457

High

390316

CXCL7
Platelet basic protein

1

20

Small-scale

0.445

High

421430

A4
Amyloid-beta precursor protein

1

7

Small-scale

0.445

High

575771

ELN
Elastin

1

20

Small-scale

0.445

High

575774

LEG3
Galectin-3

1

16

Small-scale

0.445

High

575777

CXCL2
C-X-C motif chemokine 2

1

20

Small-scale

0.445

High

575798

SCUB3
Signal peptide, CUB and EGF-like domain-containing protein 3

1

17

Small-scale

0.445

High

370535

FOS
Protein c-Fos

1

7

Small-scale

0.437

High

575773

JUND
Transcription factor JunD

1

4

Small-scale

0.437

High

575790

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.437

High

575799

FBXW8
F-box/WD repeat-containing protein 8

1

3

High-throughput

0.437

High

575804

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025