HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SPB5 (P36952)
Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)
Gene: SERPINB5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	25640309
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 375
+	Hs
		395676 ESR1_HUMAN (1-595): 0: 599: 100.00		SPB4_HUMAN (1-375): 8.47e-154: 440: 32.58
+	Hs
		713425 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SPB3_HUMAN (1-375): 1.04e-153: 440: 33.84
+	Hs
		874832 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SPB4_HUMAN (1-375): 8.47e-154: 440: 32.58
+	Hs
		369377 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		A1AT_HUMAN (2-375): 6.17e-143: 413: 25.00
+	Hs
		403856 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		ILEU_HUMAN (1-375): 1.75e-162: 461: 39.31
+	Hs
		343237 ERR2_HUMAN (92-547): 4.32e-116: 354: 34.86		SPB4_HUMAN (1-375): 8.47e-154: 440: 32.58
+	Hs
		403877 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		SPB5_HUMAN (1-375): 3.02e-152: 435: 100.00
+	Hs
		369324 HNF4A_HUMAN (146-592): 2.14e-118: 361: 20.58		A1AT_HUMAN (2-375): 6.17e-143: 413: 25.00
+	Hs
		395711 ESR1_HUMAN (1-595): 0: 599: 100.00		SERPH_HUMAN (8-375): 2.77e-43: 157: 29.30
+	Hs
		895620 ESR2_HUMAN (26-582): 8.93e-136: 408: 45.88		SERPH_HUMAN (8-375): 2.77e-43: 157: 29.30
+	Hs
		403915 GCR_HUMAN (5-557): 4.69e-109: 346: 22.51		SERPH_HUMAN (8-375): 2.77e-43: 157: 29.30
+	Hs
		789441 PPARG_HUMAN (55-546): 2.13e-100: 316: 20.35		SERPH_HUMAN (8-375): 2.77e-43: 157: 29.30