Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1
Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.974 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27703006, 28806393, 28205554, 31980649, 36244648, 38496616, 16093354, 15925322, 20130576, 17979178, 22169110, 22510884 |
| Identification Methods | affinity chromatography technology, fluorescent resonance energy transfer, proximity labelling technology, in-gel kinase assay, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification |
| Interaction Type | physical association, direct interaction, phosphorylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~C1_1, C1_1~Pkinase, C1_1~RBD, Pkinase~Pkinase, RBD~RBD |
| Common GO terms | GO:0000165 - MAPK cascade GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity GO:0004709 - MAP kinase kinase kinase activity GO:0005524 - ATP binding and 43 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
Service provided by Combinatics, Japan
Last updated: 11Aug2025