Protein: KSR1
Kinase suppressor of Ras 1 (EC 2.7.11.1)

Gene: KSR1
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q8IVT5

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005078 - MAP-kinase scaffold activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038319

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

8

20

Small-scale

0.969

High

730033

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.932

High

783618

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

5

20

Small-scale

0.918

High

966578

1433G
14-3-3 protein gamma

4

20

High-throughput

0.903

High

1049526

1433F
14-3-3 protein eta

4

20

High-throughput

0.891

High

692094

MARK3
MAP/microtubule affinity-regulating kinase 3

3

12

Small-scale

0.861

High

938116

ANM2
Protein arginine N-methyltransferase 2

3

4

High-throughput

0.861

High

971746

1433E
14-3-3 protein epsilon

3

10

High-throughput

0.855

High

990461

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.855

High

691217

1433T
14-3-3 protein theta

3

20

High-throughput

0.839

High

401108

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

18

Small-scale

0.827

High

1292781

SKAP1
Src kinase-associated phosphoprotein 1

2

20

High-throughput

0.789

High

578512

BRAF
Serine/threonine-protein kinase B-raf

2

17

Small-scale

0.776

High

730746

1433S
14-3-3 protein sigma

1

20

High-throughput

0.665

High

1294449

VRK2
Serine/threonine-protein kinase VRK2

1

20

Small-scale

0.665

High

1278907

BRAP
BRCA1-associated protein

3

6

Small-scale

0.662

High

163133

CHK1
Serine/threonine-protein kinase Chk1

1

2

High-throughput

0.618

High

176848

DCLK1
Serine/threonine-protein kinase DCLK1

1

12

High-throughput

0.618

High

245248

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

12

High-throughput

0.618

High

246025

KIF1B
Kinesin-like protein KIF1B

1

9

High-throughput

0.618

High

269579

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

18

High-throughput

0.618

High

461677

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468570

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

767254

MERL
Merlin

1

20

High-throughput

0.618

High

876923

KC1A
Casein kinase I isoform alpha

1

6

High-throughput

0.618

High

1025566

CDK16
Cyclin-dependent kinase 16

1

11

High-throughput

0.618

High

1090157

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

1092461

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

17

High-throughput

0.618

High

1129960

MELK
Maternal embryonic leucine zipper kinase

1

14

High-throughput

0.618

High

1152013

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

20

High-throughput

0.618

High

1216007

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

18

High-throughput

0.618

High

1216069

SPD2A
SH3 and PX domain-containing protein 2A

1

12

High-throughput

0.618

High

1234852

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.618

High

1256804

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

20

High-throughput

0.618

High

1286515

PHLB2
Pleckstrin homology-like domain family B member 2

1

18

High-throughput

0.618

High

1293237

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

5

High-throughput

0.618

High

1309222

KSR1
Kinase suppressor of Ras 1

1

20

Small-scale

0.618

High

1309228

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.618

High

1309237

TESK2
Dual specificity testis-specific protein kinase 2

1

19

High-throughput

0.618

High

1309249

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.618

High

1309250

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.618

High

1309265

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

15

High-throughput

0.618

High

1309267

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.618

High

1309244

CAB45
45 kDa calcium-binding protein

2

9

High-throughput

0.611

High

258970

DNJA2
DnaJ homolog subfamily A member 2

2

14

High-throughput

0.601

High

1309245

RTKN
Rhotekin

1

0

High-throughput

0.586

High

1309256

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

208531

PJA2
E3 ubiquitin-protein ligase Praja-2

1

5

Small-scale

0.578

High

943985

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.575

High

1309224

MILK1
MICAL-like protein 1

1

12

High-throughput

0.553

High

1309257

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.553

High

567018

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

5

High-throughput

0.536

High

1309238

TCPQM
T-complex protein 1 subunit theta-like 2

1

16

High-throughput

0.536

High

1309235

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

19

Small-scale

0.501

High

74541

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

7

High-throughput

0.489

High

848517

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.489

High

173032

XPO1
Exportin-1

1

12

High-throughput

0.479

High

208700

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

8

High-throughput

0.479

High

230546

KIF1C
Kinesin-like protein KIF1C

1

9

High-throughput

0.479

High

252108

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

281367

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.479

High

293974

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

342241

BRD1
Bromodomain-containing protein 1

1

5

High-throughput

0.479

High

606899

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

637923

NF1
Neurofibromin

1

20

High-throughput

0.479

High

639770

TAF1
Transcription initiation factor TFIID subunit 1

1

8

High-throughput

0.479

High

719239

MPIP2
M-phase inducer phosphatase 2

1

4

High-throughput

0.479

High

719347

MPIP3
M-phase inducer phosphatase 3

1

4

High-throughput

0.479

High

936378

AFAD
Afadin

1

20

High-throughput

0.479

High

941013

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

1045480

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1065730

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

14

High-throughput

0.479

High

1133999

ZN638
Zinc finger protein 638

1

4

High-throughput

0.479

High

1198335

CRTC2
CREB-regulated transcription coactivator 2

1

9

High-throughput

0.479

High

1219597

DEN4C
DENN domain-containing protein 4C

1

7

High-throughput

0.479

High

1245652

LARP1
La-related protein 1

1

9

High-throughput

0.479

High

1248105

CRTC3
CREB-regulated transcription coactivator 3

1

10

High-throughput

0.479

High

1251373

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.479

High

1272872

RFIP2
Rab11 family-interacting protein 2

1

12

High-throughput

0.479

High

1277697

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.479

High

1309223

RPTOR
Regulatory-associated protein of mTOR

1

14

High-throughput

0.479

High

1309225

NAV1
Neuron navigator 1

1

12

High-throughput

0.479

High

1309226

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1309227

DEN1A
DENN domain-containing protein 1A

1

7

High-throughput

0.479

High

1309229

HDAC7
Histone deacetylase 7

1

7

High-throughput

0.479

High

1309232

ARHG2
Rho guanine nucleotide exchange factor 2

1

18

Small-scale

0.479

High

1309236

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

1309241

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1309242

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1309247

OSBL6
Oxysterol-binding protein-related protein 6

1

6

High-throughput

0.479

High

1309252

KI13B
Kinesin-like protein KIF13B

1

9

High-throughput

0.479

High

1309253

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

8

High-throughput

0.479

High

1309259

LIMA1
LIM domain and actin-binding protein 1

1

8

High-throughput

0.479

High

1309260

XPO7
Exportin-7

1

8

High-throughput

0.479

High

1309261

NGAP
Ras GTPase-activating protein nGAP

1

20

High-throughput

0.479

High

1309262

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.479

High

1309263

ZBT21
Zinc finger and BTB domain-containing protein 21

1

6

High-throughput

0.479

High

1309264

PPM1H
Protein phosphatase 1H

1

2

High-throughput

0.479

High

1309266

BAIP2
BAR/IMD domain-containing adapter protein 2

1

20

High-throughput

0.479

High

1309268

HDAC5
Histone deacetylase 5

1

7

High-throughput

0.479

High

1309270

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1309271

STA13
StAR-related lipid transfer protein 13

1

15

High-throughput

0.479

High

1309272

DCAF1
DDB1- and CUL4-associated factor 1

1

8

High-throughput

0.479

High

1309239

EBP2
Probable rRNA-processing protein EBP2

1

2

High-throughput

0.470

High

339092

NADK
NAD kinase

1

0

High-throughput

0.458

High

750507

LSP1
Lymphocyte-specific protein 1

1

0

Small-scale

0.458

High

1238309

REEP3
Receptor expression-enhancing protein 3

1

0

High-throughput

0.458

High

1309233

DACT3
Dapper homolog 3

1

0

High-throughput

0.458

High

1309234

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1309243

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1309246

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

977538

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

11

Small-scale

0.445

High

991058

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

7

Small-scale

0.445

High

1143897

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

5

Small-scale

0.445

High

1143931

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

5

Small-scale

0.445

High

1158064

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

5

Small-scale

0.445

High

1227009

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.445

High

1258496

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.445

High

1309269

CLC11
C-type lectin domain family 11 member A

1

7

High-throughput

0.445

High

106230

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1187119

TBC25
TBC1 domain family member 25

1

20

High-throughput

0.437

High

1229892

AN34A
Ankyrin repeat domain-containing protein 34A

1

20

High-throughput

0.437

High

1257017

SYDE1
Rho GTPase-activating protein SYDE1

1

20

High-throughput

0.437

High

1287240

TBCD1
TBC1 domain family member 1

1

14

High-throughput

0.437

High

1309230

DEP1B
DEP domain-containing protein 1B

1

9

High-throughput

0.437

High

1309231

SRS12
Serine/arginine-rich splicing factor 12

1

11

High-throughput

0.437

High

1309251

TANC2
Protein TANC2

1

19

High-throughput

0.437

High

1309254

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

2

High-throughput

0.437

High

1309258

CING
Cingulin

1

7

High-throughput

0.437

High

1309273

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.437

High

1010941

BAT1
b(0,+)-type amino acid transporter 1

1

10

High-throughput

0.407

High

1309240

EGFL8
Epidermal growth factor-like protein 8

1

9

High-throughput

0.407

High

169193

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.249

Low

1309248

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low

1309255

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025