Protein: CBLB
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)

Gene: CBLB
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q13191

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0005509 - calcium ion binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475700

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

7

8

Small-scale

0.965

High

919717

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

11

Small-scale

0.870

High

1027602

CBLB
E3 ubiquitin-protein ligase CBL-B

2

13

Small-scale

0.778

High

924539

GRB2
Growth factor receptor-bound protein 2

17

20

Small-scale

0.766

High

1027621

SH3K1
SH3 domain-containing kinase-binding protein 1

12

20

Small-scale

0.763

High

338362

EGFR
Epidermal growth factor receptor

16

20

Small-scale

0.759

High

610384

CBL
E3 ubiquitin-protein ligase CBL

2

12

Small-scale

0.754

High

209046

NCK2
Cytoplasmic protein NCK2

7

20

High-throughput

0.753

High

1027607

NEDD8
NEDD8

1

2

Small-scale

0.724

High

655351

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

5

14

Small-scale

0.706

High

802585

CRK
Adapter molecule crk

4

20

High-throughput

0.696

High

412170

FYN
Tyrosine-protein kinase Fyn

4

20

High-throughput

0.683

High

883333

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

3

20

Small-scale

0.672

High

802834

CRKL
Crk-like protein

3

20

Small-scale

0.660

High

1027625

GORS2
Golgi reassembly-stacking protein 2

5

2

High-throughput

0.659

High

1027634

CD2AP
CD2-associated protein

2

20

Small-scale

0.654

High

932508

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

14

High-throughput

0.647

High

548699

VAV
Proto-oncogene vav

2

20

Small-scale

0.639

High

796469

ZAP70
Tyrosine-protein kinase ZAP-70

3

20

Small-scale

0.631

High

1027611

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.621

High

227340

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.618

High

1027618

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

3

20

High-throughput

0.616

High

298976

SRBS2
Sorbin and SH3 domain-containing protein 2

2

20

High-throughput

0.606

High

433339

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.606

High

1027603

PTK6
Protein-tyrosine kinase 6

2

20

High-throughput

0.606

High

1027629

VAV3
Guanine nucleotide exchange factor VAV3

2

20

High-throughput

0.606

High

1027610

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

4

High-throughput

0.602

High

1027609

DDR2
Discoidin domain-containing receptor 2

2

20

Small-scale

0.601

High

1027604

ARHG7
Rho guanine nucleotide exchange factor 7

2

18

Small-scale

0.596

High

796561

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.595

High

1027628

DP13A
DCC-interacting protein 13-alpha

2

5

High-throughput

0.594

High

724540

IRS1
Insulin receptor substrate 1

2

11

Small-scale

0.584

High

983599

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.584

High

985948

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

12

Small-scale

0.584

High

275194

GRAP2
GRB2-related adapter protein 2

2

20

High-throughput

0.576

High

280388

GLRX3
Glutaredoxin-3

1

2

High-throughput

0.573

High

808111

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

9

Small-scale

0.561

High

235501

VINEX
Vinexin

1

20

High-throughput

0.541

High

878068

ANM2
Protein arginine N-methyltransferase 2

1

1

High-throughput

0.541

High

862034

DAPK1
Death-associated protein kinase 1

1

3

High-throughput

0.536

High

1027632

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

5

High-throughput

0.536

High

178155

IPO8
Importin-8

1

2

High-throughput

0.536

High

1027624

CAR11
Caspase recruitment domain-containing protein 11

1

8

Small-scale

0.534

High

1027630

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

9

Small-scale

0.534

High

1027608

CRY1
Cryptochrome-1

1

0

High-throughput

0.518

High

181609

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

Small-scale

0.515

High

643341

HMGB2
High mobility group protein B2

1

11

High-throughput

0.515

High

1027627

ITSN2
Intersectin-2

1

20

High-throughput

0.515

High

719473

MERL
Merlin

1

6

High-throughput

0.515

High

726790

FUS
RNA-binding protein FUS

1

6

High-throughput

0.515

High

959921

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.515

High

966140

NC2B
Protein Dr1

1

1

High-throughput

0.515

High

1025723

TADBP
TAR DNA-binding protein 43

1

3

High-throughput

0.515

High

1027635

TF3C3
General transcription factor 3C polypeptide 3

1

4

High-throughput

0.515

High

1027617

SP7
Transcription factor Sp7

1

7

Small-scale

0.512

High

903915

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.501

High

1027616

ABI1
Abl interactor 1

1

20

Small-scale

0.501

High

258002

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.493

High

336486

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

1027631

RNF11
RING finger protein 11

1

0

High-throughput

0.486

High

200175

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

10

Small-scale

0.481

High

855791

VAV2
Guanine nucleotide exchange factor VAV2

1

20

Small-scale

0.481

High

1027613

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.481

High

1027620

OSTF1
Osteoclast-stimulating factor 1

1

20

High-throughput

0.481

High

122724

MEN1
Menin

1

2

High-throughput

0.479

High

129289

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

Small-scale

0.479

High

154355

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

9

Small-scale

0.479

High

195793

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

7

Small-scale

0.479

High

208354

SPY1
Protein sprouty homolog 1

1

8

Small-scale

0.479

High

255739

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

259283

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

3

Small-scale

0.479

High

337458

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.479

High

384765

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

386651

P53
Cellular tumor antigen p53

1

10

Small-scale

0.479

High

411703

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.479

High

452407

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.479

High

499262

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.479

High

522956

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.479

High

562643

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

2

Small-scale

0.479

High

589569

CD33
Myeloid cell surface antigen CD33

1

4

Small-scale

0.479

High

607956

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

666097

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

786604

STA5A
Signal transducer and activator of transcription 5A

1

3

Small-scale

0.479

High

790669

WASP
Actin nucleation-promoting factor WAS

1

7

Small-scale

0.479

High

823957

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

18

Small-scale

0.479

High

882278

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

16

High-throughput

0.479

High

887832

CD81
CD81 antigen

1

2

Small-scale

0.479

High

986370

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.479

High

1020636

TRAF2
TNF receptor-associated factor 2

1

12

Small-scale

0.479

High

1024666

TRAF3
TNF receptor-associated factor 3

1

14

Small-scale

0.479

High

1027605

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.479

High

1027606

ITSN1
Intersectin-1

1

20

Small-scale

0.479

High

1027614

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.479

High

1027615

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

5

Small-scale

0.479

High

1027622

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

Small-scale

0.479

High

1027623

MYD88
Myeloid differentiation primary response protein MyD88

1

2

Small-scale

0.479

High

1027633

TRAF6
TNF receptor-associated factor 6

1

14

Small-scale

0.479

High

1027619

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.458

High

1027626

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

69208

A9UF07
non-specific protein-tyrosine kinase

1

20

High-throughput

0.445

High

182150

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

7

Small-scale

0.445

High

262263

ULK1
Serine/threonine-protein kinase ULK1

1

2

Small-scale

0.445

High

557678

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.445

High

161200

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.316

High

1027612

Q6NUL7
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024