HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 238
+	Hs
		401162 RAF1_HUMAN (1-648): 0: 637: 100.00		RB15B_HUMAN (4-232): 1.78e-31: 123: 22.41
+	Hs
		401199 RAF1_HUMAN (1-648): 0: 637: 100.00		PPIL4_HUMAN (1-84): 1.76e-25: 105: 26.97
+	Hs
		400516 RAF1_HUMAN (1-648): 0: 637: 100.00		NCBP2_HUMAN (10-114): 8.11e-26: 100: 23.42
+	Hs
		400142 RAF1_HUMAN (1-648): 0: 637: 100.00		HNRPC_HUMAN (3-186): 3.01e-24: 99: 22.58
+	Hs
		400772 RAF1_HUMAN (1-648): 0: 637: 100.00		PABP4_HUMAN (6-163): 5.37e-21: 93.2: 16.15
+	Hs
		400709 RAF1_HUMAN (1-648): 0: 637: 100.00		SRSF1_HUMAN (10-81): 4.53e-21: 90.3: 48.65
+	Hs
		400202 RAF1_HUMAN (1-648): 0: 637: 100.00		PABP1_HUMAN (6-96): 2.86e-19: 88.2: 22.34
+	Hs
		401376 RAF1_HUMAN (1-648): 0: 637: 100.00		RBM4B_HUMAN (12-89): 7.43e-17: 80.2: 32.05
+	Hs
		400667 RAF1_HUMAN (1-648): 0: 637: 100.00		TIAR_HUMAN (5-97): 5.71e-16: 77.8: 25.51
+	Hs
		521336 ARAF_HUMAN (44-646): 8.15e-165: 486: 59.18		PABP4_HUMAN (6-163): 5.37e-21: 93.2: 16.15
+	Hs
		521177 ARAF_HUMAN (44-646): 8.15e-165: 486: 59.18		PABP1_HUMAN (6-96): 2.86e-19: 88.2: 22.34
+	Zm
		42001 A0A1D6QQC6_MAIZE (247-611): 5.96e-109: 350: 28.80		A0A1D6NTG8_MAIZE (11-122): 3.32e-33: 121: 46.43
+	Hs
		1309231 KSR1_HUMAN (138-648): 4.19e-108: 349: 24.61		SRS12_HUMAN (1-218): 8.53e-28: 108: 32.60
+	Hs
		462221 SRC_HUMAN (331-607): 2.21e-106: 334: 33.45		HNRPC_HUMAN (3-186): 3.01e-24: 99: 22.58
+	Hs
		462201 YES_HUMAN (329-607): 9.75e-106: 332: 33.92		HNRPC_HUMAN (3-186): 3.01e-24: 99: 22.58
+	Hs
		557280 SRC_HUMAN (331-607): 2.21e-106: 334: 33.45		PABP4_HUMAN (6-163): 5.37e-21: 93.2: 16.15
+	Hs
		550100 SRC_HUMAN (331-607): 2.21e-106: 334: 33.45		PABP1_HUMAN (6-96): 2.86e-19: 88.2: 22.34
+	Hs
		557468 SRC_HUMAN (331-607): 2.21e-106: 334: 33.45		PABP3_HUMAN (6-108): 1.47e-17: 83.2: 20.76