HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 1025
+	Hs
		401255 RAF1_HUMAN (1-648): 0: 637: 100.00		CNKR1_HUMAN (351-693): 2.43e-66: 239: 21.04
+	Hs
		401189 RAF1_HUMAN (1-648): 0: 637: 100.00		DLG5_HUMAN (647-1019): 8.92e-54: 207: 21.61
+	Mm
		1000208 RAF1_MOUSE (1-648): 0: 632: 97.69		ROCK2_MOUSE (502-969): 1.57e-40: 165: 18.71
+	Hs
		400976 RAF1_HUMAN (1-648): 0: 637: 100.00		MRCKA_HUMAN (418-981): 1.19e-30: 133: 12.40
+	Hs
		400389 RAF1_HUMAN (1-648): 0: 637: 100.00		MYH10_HUMAN (242-1024): 1.66e-21: 103: 8.45
+	Hs
		578530 BRAF_HUMAN (39-647): 9.6e-166: 494: 56.02		CNKR1_HUMAN (351-693): 2.43e-66: 239: 21.04
+	Hs
		400388 RAF1_HUMAN (1-648): 0: 637: 100.00		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		400392 RAF1_HUMAN (1-648): 0: 637: 100.00		MYH11_HUMAN (124-786): 5.18e-12: 72.4: 11.57
+	Hs
		400862 RAF1_HUMAN (1-648): 0: 637: 100.00		PLEC_HUMAN (499-978): 3.11e-11: 70.1: 14.96
+	Hs
		401052 RAF1_HUMAN (1-648): 0: 637: 100.00		MYH14_HUMAN (595-972): 3.71e-09: 63.1: 14.89
+	Hs
		1234852 KSR1_HUMAN (138-648): 4.19e-108: 349: 24.61		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		1309250 KSR1_HUMAN (138-648): 4.19e-108: 349: 24.61		PKHA5_HUMAN (318-1019): 2.96e-36: 151: 13.24
+	Hs
		463129 YES_HUMAN (329-607): 9.75e-106: 332: 33.92		PKHA7_HUMAN (336-980): 2.5e-41: 167: 13.51
+	Hs
		117127 J3QRU1_HUMAN (329-607): 1.13e-105: 332: 33.92		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		463006 YES_HUMAN (329-607): 9.75e-106: 332: 33.92		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35
+	Hs
		440414 FYN_HUMAN (337-607): 1.87e-103: 326: 34.55		MYH9_HUMAN (528-991): 3.25e-16: 86.3: 11.35