HitPredict

Interactor 1: GCR (P04150)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
Gene: NR3C1

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	12730237
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 248
+	Hs
		403997 GCR_HUMAN (1-777): 0: 913: 100.00		1433F_HUMAN (2-242): 2.79e-96: 283: 64.20
+	Hs
		395577 ESR1_HUMAN (263-760): 1.14e-130: 403: 23.06		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		395821 ESR1_HUMAN (263-760): 1.14e-130: 403: 23.06		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Hs
		395860 ESR1_HUMAN (263-760): 1.14e-130: 403: 23.06		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		730807 ESR2_HUMAN (286-769): 4.86e-108: 342: 21.34		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		971846 ESR2_HUMAN (286-769): 4.86e-108: 342: 21.34		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	Hs
		519924 ANDR_HUMAN (357-777): 7.83e-108: 352: 45.60		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Hs
		990568 ESR2_HUMAN (286-769): 4.86e-108: 342: 21.34		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Mm
		542846 RARA_MOUSE (316-759): 2.74e-105: 332: 19.82		1433Z_MOUSE (1-243): 1.35e-136: 385: 69.96
+	Hs
		395529 ESR1_HUMAN (263-760): 1.14e-130: 403: 23.06		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		395576 ESR1_HUMAN (263-760): 1.14e-130: 403: 23.06		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		395814 ESR1_HUMAN (263-760): 1.14e-130: 403: 23.06		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Hs
		343224 ERR2_HUMAN (316-761): 9.39e-117: 361: 24.44		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		519760 ANDR_HUMAN (357-777): 7.83e-108: 352: 45.60		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		467784 MCR_HUMAN (140-777): 5.6e-115: 373: 39.46		1433F_HUMAN (2-242): 2.79e-96: 283: 64.20
+	Hs
		691304 ESR2_HUMAN (286-769): 4.86e-108: 342: 21.34		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		519970 ANDR_HUMAN (357-777): 7.83e-108: 352: 45.60		1433F_HUMAN (2-242): 2.79e-96: 283: 64.20
+	Hs
		730115 ESR2_HUMAN (286-769): 4.86e-108: 342: 21.34		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Hs
		966698 ESR2_HUMAN (286-769): 4.86e-108: 342: 21.34		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Mm
		542837 RARA_MOUSE (316-759): 2.74e-105: 332: 19.82		1433G_MOUSE (1-242): 1.87e-98: 289: 65.16