HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29509190, 11266503
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 530
+	Hs
		971846 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		990568 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		730115 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		395821 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		395529 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		395860 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		395576 1433B_HUMAN (1-242): 5.04e-139: 391: 81.82		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Hs
		730807 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		ESR2_HUMAN (1-530): 2.39e-157: 460: 100.00
+	Hs
		343224 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ERR2_HUMAN (69-499): 5.89e-109: 333: 31.57
+	Hs
		395577 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Mm
		542846 1433Z_MOUSE (1-245): 3.08e-142: 399: 80.00		RARA_MOUSE (52-508): 5.9e-105: 324: 23.58
+	Hs
		395814 1433G_HUMAN (1-242): 5.51e-105: 305: 70.33		ESR1_HUMAN (9-529): 3.59e-138: 413: 44.56
+	Mm
		542884 1433B_MOUSE (1-242): 2.85e-124: 354: 80.99		RARA_MOUSE (52-508): 5.9e-105: 324: 23.58
+	Hs
		403861 1433S_HUMAN (1-236): 9.9e-108: 312: 71.85		GCR_HUMAN (3-495): 1.13e-103: 330: 22.64
+	Hs
		403997 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		GCR_HUMAN (3-495): 1.13e-103: 330: 22.64
+	Mm
		542837 1433G_MOUSE (1-242): 5.51e-105: 305: 70.33		RARA_MOUSE (52-508): 5.9e-105: 324: 23.58
+	Hs
		519760 1433T_HUMAN (1-245): 9.51e-142: 398: 100.00		ANDR_HUMAN (149-407): 8.13e-38: 150: 32.59
+	Hs
		519924 1433Z_HUMAN (1-245): 1.76e-141: 397: 79.59		ANDR_HUMAN (149-407): 8.13e-38: 150: 32.59
+	Hs
		467784 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		MCR_HUMAN (141-408): 5.94e-38: 150: 34.03
+	Hs
		519970 1433F_HUMAN (2-242): 7.19e-106: 307: 71.43		ANDR_HUMAN (149-407): 8.13e-38: 150: 32.59