HitPredict

Interactor 1: JUN (P05627)
Transcription factor Jun (AH119) (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A)
Gene: JUN

Interactor 2: MK08 (Q91Y86)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: Mapk8

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.755

The method score is based on:

Property Details
Experiments 12223491, 9687507, 21538482, 17276034, 17158449, 10748240, 15288121, 15218018, 15767678, 17255944, 10581243
Identification Methods enzymatic study, affinity chromatography technology, protein kinase assay, in-gel kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006355 - regulation of DNA-templated transcription
GO:0043065 - positive regulation of apoptotic process
GO:0043066 - negative regulation of apoptotic process
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 334
Mm

1 384
+ Rn
+ Rn
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
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+ Dm
+ Dm
+ Dm
+ Hs
+ Hs

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Last updated: 15 Jul 2024