HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043235 - receptor complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 455
+	Hs
		163221 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		TR10B_HUMAN (39-445): 5.55e-78: 251: 20.43
+	Hs
		127621 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		TR10A_HUMAN (51-445): 3.79e-66: 221: 17.57
+	Hs
		362749 EGFR_HUMAN (16-1253): 0: 1078: 48.80		TNR1A_HUMAN (1-455): 2.08e-147: 429: 100.00
+	Hs
		410674 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		TNR3_HUMAN (11-328): 2.09e-62: 210: 24.85
+	Hs
		284496 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		TNR21_HUMAN (38-339): 3.41e-52: 187: 16.23
+	Hs
		410631 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		TNR6_HUMAN (1-167): 1.19e-46: 165: 23.21
+	Hs
		410988 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		TR19L_HUMAN (61-342): 3.93e-34: 134: 15.64
+	Hs
		163216 EGFR_HUMAN (16-1253): 0: 1078: 48.80		TR10B_HUMAN (39-445): 5.55e-78: 251: 20.43
+	Hs
		364106 EGFR_HUMAN (16-1253): 0: 1078: 48.80		TNR11_HUMAN (43-368): 1.87e-47: 174: 16.43
+	Hs
		710571 EPHA2_HUMAN (671-1023): 3.2e-117: 391: 33.06		EDAR_HUMAN (37-450): 3.33e-76: 246: 13.99
+	Hs
		253295 JAK2_HUMAN (666-1020): 1.24e-44: 178: 18.38		TNR1A_HUMAN (1-455): 2.08e-147: 429: 100.00
+	Hs
		622519 JAK1_HUMAN (669-1035): 3.64e-43: 174: 19.38		TNR1A_HUMAN (1-455): 2.08e-147: 429: 100.00
+	Hs
		932012 EPHB4_HUMAN (707-1000): 4.96e-53: 204: 38.21		EDAR_HUMAN (37-450): 3.33e-76: 246: 13.99
+	Hs
		658793 JAK1_HUMAN (669-1035): 3.64e-43: 174: 19.38		EDAR_HUMAN (37-450): 3.33e-76: 246: 13.99
+	Hs
		658750 JAK1_HUMAN (669-1035): 3.64e-43: 174: 19.38		TR19L_HUMAN (61-342): 3.93e-34: 134: 15.64