HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SEM6D (Q8NFY4)
Semaphorin-6D
Gene: SEMA6D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0071526 - semaphorin-plexin signaling pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 1073
+	Hs
		363588 EGFR_HUMAN (16-1253): 0: 1078: 48.80		SEM6D_HUMAN (1-1073): 0: 1385: 100.00
+	Hs
		410846 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SEM3A_HUMAN (1-628): 0: 673: 29.54
+	Hs
		325228 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SEM3D_HUMAN (8-628): 0: 667: 30.85
+	Hs
		411022 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SEM3C_HUMAN (9-628): 0: 635: 27.39
+	Hs
		710374 EPHA2_HUMAN (671-1023): 3.2e-117: 391: 33.06		SEM6D_HUMAN (1-1073): 0: 1385: 100.00
+	Hs
		363779 EGFR_HUMAN (16-1253): 0: 1078: 48.80		SEM3C_HUMAN (9-628): 0: 635: 27.39
+	Hs
		710483 EPHA2_HUMAN (671-1023): 3.2e-117: 391: 33.06		SEM6A_HUMAN (8-1067): 0: 1166: 44.89
+	Hs
		1098312 EPHA7_HUMAN (664-1030): 1.99e-121: 403: 30.61		SEM3B_HUMAN (1-627): 0: 637: 29.17
+	Hs
		710472 EPHA2_HUMAN (671-1023): 3.2e-117: 391: 33.06		SEM4C_HUMAN (7-609): 0: 584: 28.14
+	Hs
		1147447 EPHA7_HUMAN (664-1030): 1.99e-121: 403: 30.61		SEM4G_HUMAN (3-611): 1.14e-180: 550: 26.97