HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase, SH2~fn3, SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1997
+	Hs
		411997 FYN_HUMAN (30-507): 0: 586: 59.01		PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23
+	Hs
		522756 SRC_HUMAN (20-507): 0: 586: 55.00		PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23
+	Mm
		411913 LCK_MOUSE (1-509): 0: 657: 96.86		PTPRC_MOUSE (1703-1980): 5.29e-70: 262: 25.99
+	Hs
		411565 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82
+	Mm
		56907 FYN_MOUSE (30-507): 0: 586: 58.80		PTPRF_MOUSE (1637-1964): 1.5e-87: 321: 33.13
+	Hs
		412016 FYN_HUMAN (30-507): 0: 586: 59.01		PTPRD_HUMAN (902-1709): 1.7e-69: 262: 12.33
+	Hs
		411959 FYN_HUMAN (30-507): 0: 586: 59.01		PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82
+	Hs
		411557 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		412017 FYN_HUMAN (30-507): 0: 586: 59.01		PTPRE_HUMAN (1683-1964): 1.22e-49: 191: 35.37
+	Mm
		574000 FYN_MOUSE (30-507): 0: 586: 58.80		PTPRA_MOUSE (1683-1966): 1.22e-48: 190: 35.29
+	Hs
		411740 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46
+	Hs
		411598 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRZ_HUMAN (1703-1976): 2.1e-23: 111: 30.96
+	Hs
		411597 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60
+	Hs
		411609 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRM_HUMAN (475-856): 6.84e-19: 96.2: 12.16
+	Hs
		411695 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75
+	Hs
		411728 LCK_HUMAN (1-509): 0: 661: 100.00		PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10
+	Hs
		362685 FYN_HUMAN (30-507): 0: 586: 59.01		FINC_HUMAN (1147-1761): 1.77e-33: 144: 15.13
+	Hs
		411950 FYN_HUMAN (30-507): 0: 586: 59.01		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		441169 SRC_HUMAN (20-507): 0: 586: 55.00		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		412018 FYN_HUMAN (30-507): 0: 586: 59.01		PTPRZ_HUMAN (1703-1976): 2.1e-23: 111: 30.96