HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	25814554, unassigned1126, 18070987
Identification Methods	two hybrid, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005102 - signaling receptor binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0019903 - protein phosphatase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 770
+	Hs
		442788 HCK_HUMAN (1-509): 0: 602: 65.04		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		412065 FYN_HUMAN (30-507): 0: 586: 59.01		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		522829 SRC_HUMAN (20-507): 0: 586: 55.00		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		403422 SRC_MOUSE (28-507): 0: 583: 57.05		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		433628 LYN_HUMAN (1-509): 0: 582: 62.72		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		454804 FGR_HUMAN (1-507): 0: 579: 52.76		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776611 BLK_HUMAN (1-509): 0: 557: 59.35		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776597 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		729741 BTK_MOUSE (7-505): 6.84e-168: 491: 32.89		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		776660 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		522836 SRC_HUMAN (20-507): 0: 586: 55.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		337403 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		337381 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		786602 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		849890 PTK6_HUMAN (63-499): 1.36e-161: 467: 40.41		STA5B_HUMAN (1-734): 0: 752: 30.55