HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 7388
+	Hs
		434078 LYN_HUMAN (1-509): 0: 582: 62.72		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		411581 LCK_HUMAN (1-509): 0: 661: 100.00		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		411682 LCK_HUMAN (1-509): 0: 661: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164551 LCK_HUMAN (1-509): 0: 661: 100.00		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		411676 LCK_HUMAN (1-509): 0: 661: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		411637 LCK_HUMAN (1-509): 0: 661: 100.00		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		411724 LCK_HUMAN (1-509): 0: 661: 100.00		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		411715 LCK_HUMAN (1-509): 0: 661: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		411983 FYN_HUMAN (30-507): 0: 586: 59.01		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		433558 LYN_HUMAN (1-509): 0: 582: 62.72		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		433543 LYN_HUMAN (1-509): 0: 582: 62.72		DMD_HUMAN (239-1700): 1.65e-14: 84.4: 8.22
+	Hs
		433710 LYN_HUMAN (1-509): 0: 582: 62.72		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164555 LYN_HUMAN (1-509): 0: 582: 62.72		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		521454 SRC_HUMAN (20-507): 0: 586: 55.00		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		433700 LYN_HUMAN (1-509): 0: 582: 62.72		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		433640 LYN_HUMAN (1-509): 0: 582: 62.72		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (757-1741): 1.73e-10: 70.9: 10.05
+	Hs
		433753 LYN_HUMAN (1-509): 0: 582: 62.72		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		337470 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		521527 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07