HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26512138
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0042169 - SH2 domain binding GO:0045121 - membrane raft
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Mm			1 429
+	Mm
		763390 FYN_MOUSE (1-507): 0: 590: 53.85		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Mm
		639443 LYN_MOUSE (1-509): 0: 567: 62.72		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		411873 LCK_HUMAN (1-509): 0: 634: 96.86		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		412375 FYN_HUMAN (1-507): 0: 591: 54.03		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		523175 SRC_HUMAN (2-507): 0: 576: 54.13		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Mm
		976830 ITK_MOUSE (6-500): 5.25e-168: 490: 33.20		PHAG1_MOUSE (1-429): 0: 785: 100.00
+	Hs
		434038 LYN_HUMAN (1-509): 0: 566: 63.37		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		789135 FRK_HUMAN (33-503): 0: 523: 47.24		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		337571 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		PHAG1_HUMAN (1-429): 0: 705: 78.21
+	Hs
		782829 CSK_HUMAN (59-500): 2.05e-174: 500: 37.80		PHAG1_HUMAN (1-429): 0: 705: 78.21