Protein: GNA12
Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)

Gene: GNA12
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q03113

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

989723

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

3

13

High-throughput

0.847

High

1040975

ARHG1
Rho guanine nucleotide exchange factor 1

2

19

Small-scale

0.799

High

1040969

GNA13
Guanine nucleotide-binding protein subunit alpha-13

2

13

High-throughput

0.789

High

720661

AGTR1
Type-1 angiotensin II receptor

1

12

High-throughput

0.698

High

1040979

RIC8A
Chaperone Ric-8A

1

14

High-throughput

0.691

High

351891

S1PR4
Sphingosine 1-phosphate receptor 4

1

20

Small-scale

0.647

High

521321

ARAF
Serine/threonine-protein kinase A-Raf

2

7

Small-scale

0.629

High

177377

ARHGB
Rho guanine nucleotide exchange factor 11

1

20

Small-scale

0.618

High

640508

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.618

High

641905

DRD5
D(1B) dopamine receptor

1

10

Small-scale

0.618

High

669383

PAR1
Proteinase-activated receptor 1

1

19

Small-scale

0.618

High

1040967

AKP13
A-kinase anchor protein 13

1

17

Small-scale

0.618

High

1040972

ARG28
Rho guanine nucleotide exchange factor 28

1

13

Small-scale

0.618

High

1040981

ARHGC
Rho guanine nucleotide exchange factor 12

1

14

Small-scale

0.618

High

475954

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

12

High-throughput

0.575

High

916645

PPP5
Serine/threonine-protein phosphatase 5

1

3

Small-scale

0.561

High

461378

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.552

High

689942

IL3RA
Interleukin-3 receptor subunit alpha

1

1

High-throughput

0.541

High

948057

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

20

High-throughput

0.536

High

983457

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

20

High-throughput

0.536

High

992411

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

20

High-throughput

0.536

High

421960

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

436660

KPCB
Protein kinase C beta type

1

8

Small-scale

0.501

High

556027

CADH1
Cadherin-1

1

5

Small-scale

0.501

High

618244

CADH2
Cadherin-2

1

5

Small-scale

0.501

High

937604

CAD15
Cadherin-15

1

5

Small-scale

0.501

High

1034982

KPCE
Protein kinase C epsilon type

1

6

Small-scale

0.501

High

1040965

KPCD
Protein kinase C delta type

1

8

Small-scale

0.501

High

375432

RASK
GTPase KRas

1

11

High-throughput

0.479

High

597356

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

20

Small-scale

0.479

High

772382

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

840873

TEC
Tyrosine-protein kinase Tec

1

1

Small-scale

0.479

High

862056

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

1040970

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

Small-scale

0.479

High

1040974

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1040976

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

10

Small-scale

0.479

High

1040983

ALK
ALK tyrosine kinase receptor

1

8

High-throughput

0.479

High

717776

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.458

High

765421

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

1040968

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

1040973

CD177
CD177 antigen

1

4

Small-scale

0.445

High

1040982

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.445

High

1040966

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.437

High

1040971

CDC73
Parafibromin

1

1

High-throughput

0.437

High

1040977

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

8

High-throughput

0.437

High

1040980

ANLN
Anillin

1

8

High-throughput

0.437

High

337643

GNAS3
Neuroendocrine secretory protein 55

1

0

High-throughput

0.426

High

1040978

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.279

Low

595405

H15
Histone H1.5

1

0

High-throughput

0.249

Low

904623

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

958934

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025