HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	9756930, 38117590
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 646
+	Hs
		522843 SRC_HUMAN (1-537): 0: 598: 68.21		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		433279 YES_HUMAN (1-537): 0: 591: 71.61		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		433634 LYN_HUMAN (1-535): 0: 535: 54.48		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		297881 FYN_HUMAN (1-537): 0: 643: 100.00		NFASC_HUMAN (35-643): 5.15e-62: 225: 13.39
+	Hs
		434019 LYN_HUMAN (1-535): 0: 535: 54.48		ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69
+	Hs
		433742 LYN_HUMAN (1-535): 0: 535: 54.48		PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68
+	Hs
		297880 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		NFASC_HUMAN (35-643): 5.15e-62: 225: 13.39
+	Dm
		219802 ABL_DROME (4-537): 3.97e-166: 513: 38.01		O44924_DROME (337-636): 3.76e-37: 151: 12.35
+	Hs
		433947 LYN_HUMAN (1-535): 0: 535: 54.48		KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77
+	Hs
		434111 LYN_HUMAN (1-535): 0: 535: 54.48		ROBO1_HUMAN (17-271): 4.39e-21: 100: 14.29