HitPredict

Interactor 1: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Interactor 2: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	9219533, 9053846, 8647086, 8626527, 9885575, 9190208, 12676926, 10486249
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction and 1 others more... GO:0051301 - cell division
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 928 Hs			1 432
+	Hs
		414240 RB_HUMAN (1-928): 0: 1323: 100.00		CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46
+	Hs
		414150 RB_HUMAN (1-928): 0: 1323: 100.00		CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71
+	Hs
		590128 RBL1_HUMAN (598-875): 2.06e-76: 272: 28.92		CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00
+	Hs
		590169 RBL2_HUMAN (638-875): 1.32e-58: 220: 26.87		CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00
+	Hs
		660112 RBL1_HUMAN (598-875): 2.06e-76: 272: 28.92		CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46
+	Hs
		943777 RBL2_HUMAN (638-875): 1.32e-58: 220: 26.87		CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46
+	Hs
		538529 RBL2_HUMAN (638-875): 1.32e-58: 220: 26.87		CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71