HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	23358872
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 393 Hs			1 861
+	Hs
		414411 P53_HUMAN (1-393): 0: 619: 100.00		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		131656 P53_HUMAN (1-393): 0: 619: 100.00		WWP2_HUMAN (355-855): 2.68e-169: 514: 18.43
+	Hs
		414591 P53_HUMAN (1-393): 0: 619: 100.00		WWP1_HUMAN (355-855): 1.14e-168: 514: 18.51
+	Hs
		414662 P53_HUMAN (1-393): 0: 619: 100.00		SMUF1_HUMAN (363-855): 6.58e-168: 507: 19.33
+	Hs
		414112 P53_HUMAN (1-393): 0: 619: 100.00		HUWE1_HUMAN (327-854): 2.82e-151: 494: 19.37
+	Hs
		414761 P53_HUMAN (1-393): 0: 619: 100.00		HECW2_HUMAN (368-855): 1.16e-149: 481: 20.00
+	Hs
		414084 P53_HUMAN (1-393): 0: 619: 100.00		HECW1_HUMAN (368-855): 3.78e-145: 469: 19.16
+	Mm
		382498 P53_MOUSE (1-393): 0: 589: 77.35		HUWE1_MOUSE (327-854): 4.68e-151: 494: 19.37
+	Hs
		186788 P73_HUMAN (13-362): 2.36e-166: 481: 39.74		ITCH_HUMAN (337-855): 6.29e-174: 528: 18.22
+	Hs
		186717 P73_HUMAN (13-362): 2.36e-166: 481: 39.74		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		131584 P73_HUMAN (13-362): 2.36e-166: 481: 39.74		WWP2_HUMAN (355-855): 2.68e-169: 514: 18.43
+	Hs
		186802 P73_HUMAN (13-362): 2.36e-166: 481: 39.74		WWP1_HUMAN (355-855): 1.14e-168: 514: 18.51
+	Hs
		186812 P73_HUMAN (13-362): 2.36e-166: 481: 39.74		HECW2_HUMAN (368-855): 1.16e-149: 481: 20.00
+	Hs
		861777 P63_HUMAN (28-363): 2.36e-145: 429: 42.11		NEDD4_HUMAN (374-853): 2.31e-168: 525: 20.53
+	Hs
		342722 P53_HUMAN (1-393): 0: 619: 100.00		HERC2_HUMAN (237-368): 1.38e-43: 174: 36.84
+	Mm
		382478 P53_MOUSE (1-393): 0: 589: 77.35		HERC2_MOUSE (237-368): 2.83e-43: 173: 36.84
+	Hs
		413883 P53_HUMAN (1-393): 0: 619: 100.00		UBE3C_HUMAN (495-845): 2.67e-20: 99: 27.64
+	Hs
		414164 P53_HUMAN (1-393): 0: 619: 100.00		CUL9_HUMAN (245-370): 1.19e-18: 94: 40.63
+	Hs
		413849 P53_HUMAN (1-393): 0: 619: 100.00		CUL7_HUMAN (245-370): 1.56e-18: 93.6: 40.63
+	Hs
		186755 P73_HUMAN (13-362): 2.36e-166: 481: 39.74		UBE3C_HUMAN (495-845): 2.67e-20: 99: 27.64