HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	20679368, 37827155, 8397207, 8397206
Identification Methods	affinity chromatography technology, proximity labelling technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006260 - DNA replication GO:0006281 - DNA repair
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 616
+	Hs
		625131 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650972 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650973 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		RFA1_HUMAN (1-616): 0: 781: 100.00