Protein: RCC1
Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)

Gene: RCC1
Organism: Homo sapiens
Interactions: 176
UniProt ID: P18754

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0000794 - condensed nuclear chromosome
GO:0003682 - chromatin binding
GO:0005085 - guanyl-nucleotide exchange factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

616292

RAN
GTP-binding nuclear protein Ran

17

8

Small-scale

0.765

High

142484

IMA3
Importin subunit alpha-3

5

2

Small-scale

0.720

High

616263

RANG
Ran-specific GTPase-activating protein

4

9

High-throughput

0.699

High

138626

IMA4
Importin subunit alpha-4

4

2

Small-scale

0.696

High

616316

IMB1
Importin subunit beta-1

5

0

Small-scale

0.692

High

259417

BRD4
Bromodomain-containing protein 4

4

5

High-throughput

0.676

High

616296

UBC9
SUMO-conjugating enzyme UBC9

3

10

High-throughput

0.675

High

66735

RGPD3
RanBP2-like and GRIP domain-containing protein 3

3

10

High-throughput

0.667

High

161590

RGPD8
RANBP2-like and GRIP domain-containing protein 8

3

10

High-throughput

0.667

High

616265

RAGP1
Ran GTPase-activating protein 1

3

2

High-throughput

0.667

High

616272

RBP2
E3 SUMO-protein ligase RanBP2

3

4

High-throughput

0.667

High

616343

NAV1
Neuron navigator 1

3

4

High-throughput

0.667

High

616352

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

3

10

High-throughput

0.667

High

616358

NUSAP
Nucleolar and spindle-associated protein 1

3

0

High-throughput

0.638

High

172457

XPO1
Exportin-1

2

5

Small-scale

0.629

High

616370

RANB3
Ran-binding protein 3

2

9

Small-scale

0.625

High

616329

H2B2E
Histone H2B type 2-E

2

6

Small-scale

0.619

High

616281

FOXA1
Hepatocyte nuclear factor 3-alpha

2

5

High-throughput

0.611

High

616323

DLGP5
Disks large-associated protein 5

2

0

High-throughput

0.602

High

418822

H2A1B
Histone H2A type 1-B/E

2

5

High-throughput

0.601

High

616259

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

6

High-throughput

0.600

High

616290

H4
Histone H4

2

3

Small-scale

0.595

High

371120

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

616305

EP300
Histone acetyltransferase p300

2

6

High-throughput

0.584

High

616350

OTUB1
Ubiquitin thioesterase OTUB1

2

2

High-throughput

0.571

High

616364

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

3

High-throughput

0.571

High

616253

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.549

High

616285

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

5

High-throughput

0.549

High

616357

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

1

0

Small-scale

0.544

High

616269

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.543

High

133081

FOXE1
Forkhead box protein E1

1

4

High-throughput

0.536

High

135484

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

187002

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.536

High

288065

FOXH1
Forkhead box protein H1

1

8

High-throughput

0.536

High

352320

TOP3B
DNA topoisomerase 3-beta-1

1

2

High-throughput

0.536

High

515773

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

11

High-throughput

0.536

High

616255

LMNB1
Lamin-B1

1

6

High-throughput

0.536

High

616271

NU153
Nuclear pore complex protein Nup153

1

13

High-throughput

0.536

High

616295

SUMO1
Small ubiquitin-related modifier 1

1

2

High-throughput

0.536

High

616297

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.536

High

616317

NUMA1
Nuclear mitotic apparatus protein 1

1

7

High-throughput

0.536

High

616325

MARE1
Microtubule-associated protein RP/EB family member 1

1

2

High-throughput

0.536

High

616332

DJC21
DnaJ homolog subfamily C member 21

1

4

High-throughput

0.536

High

616337

FOXI2
Forkhead box protein I2

1

3

High-throughput

0.536

High

616354

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.536

High

616355

VRK1
Serine/threonine-protein kinase VRK1

1

4

Small-scale

0.536

High

616361

FOXQ1
Forkhead box protein Q1

1

7

High-throughput

0.536

High

616366

FOXP1
Forkhead box protein P1

1

3

High-throughput

0.536

High

616376

HDAC9
Histone deacetylase 9

1

6

High-throughput

0.536

High

601552

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.527

High

616299

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

616304

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

616367

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.513

High

156593

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

5

High-throughput

0.508

High

344861

WIZ
Protein Wiz

1

1

High-throughput

0.508

High

413158

P53
Cellular tumor antigen p53

1

6

High-throughput

0.508

High

539109

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.508

High

561271

HXD8
Homeobox protein Hox-D8

1

1

High-throughput

0.508

High

572980

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.508

High

616276

APLP1
Amyloid beta precursor like protein 1

1

1

High-throughput

0.508

High

616284

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.508

High

616293

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.508

High

616303

TLE1
Transducin-like enhancer protein 1

1

5

High-throughput

0.508

High

616306

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.508

High

616313

TBB3
Tubulin beta-3 chain

1

7

High-throughput

0.508

High

616339

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.508

High

616353

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.508

High

616377

KMT2B
Histone-lysine N-methyltransferase 2B

1

3

High-throughput

0.508

High

616378

FAF1
FAS-associated factor 1

1

3

High-throughput

0.508

High

616381

CSAD
Cysteine sulfinic acid decarboxylase

1

1

High-throughput

0.508

High

185417

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

616286

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

616298

H31
Histone H3.1

1

9

Small-scale

0.501

High

616302

ERCC6
DNA excision repair protein ERCC-6

1

4

High-throughput

0.501

High

616328

H2A2C
Histone H2A type 2-C

1

5

Small-scale

0.501

High

616256

FGFR2
Fibroblast growth factor receptor 2

1

4

High-throughput

0.500

High

616320

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

389010

FINC
Fibronectin

1

3

High-throughput

0.489

High

616331

CCD93
Coiled-coil domain-containing protein 93

1

1

High-throughput

0.489

High

228168

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

299465

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

0

High-throughput

0.486

High

466559

TNR16
Tumor necrosis factor receptor superfamily member 16

1

0

High-throughput

0.486

High

616279

ZN135
Zinc finger protein 135

1

0

High-throughput

0.486

High

616280

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.486

High

616333

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.486

High

616356

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.486

High

616267

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.481

High

616379

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

125217

LEG9
Galectin-9

1

1

High-throughput

0.479

High

240707

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

247661

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

271885

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

277551

H2AY
Core histone macro-H2A.1

1

6

Small-scale

0.479

High

315098

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

400251

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

408662

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

507507

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

Small-scale

0.479

High

587882

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

591470

H2AX
Histone H2AX

1

6

High-throughput

0.479

High

605164

TAL1
T-cell acute lymphocytic leukemia protein 1

1

4

Small-scale

0.479

High

616257

BRD2
Bromodomain-containing protein 2

1

10

High-throughput

0.479

High

616258

DNJB2
DnaJ homolog subfamily B member 2

1

3

High-throughput

0.479

High

616260

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

616261

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

616266

ATRX
Transcriptional regulator ATRX

1

4

High-throughput

0.479

High

616268

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

616273

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

616274

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.479

High

616275

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

616278

HDGF
Hepatoma-derived growth factor

1

5

High-throughput

0.479

High

616287

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

616288

NTF2
Nuclear transport factor 2

1

2

High-throughput

0.479

High

616291

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.479

High

616300

VIGLN
Vigilin

1

2

High-throughput

0.479

High

616301

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

616309

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

616310

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.479

High

616312

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

616314

CUL3
Cullin-3

1

8

High-throughput

0.479

High

616315

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

616318

CUL7
Cullin-7

1

4

High-throughput

0.479

High

616319

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

4

High-throughput

0.479

High

616321

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

616322

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

616327

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

616335

H2A2A
Histone H2A type 2-A

1

5

High-throughput

0.479

High

616338

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

616341

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

616346

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

616347

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

616349

MBD6
Methyl-CpG-binding domain protein 6

1

5

High-throughput

0.479

High

616351

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.479

High

616359

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

616363

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

616365

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

616369

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

616371

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

616372

RCC2
Protein RCC2

1

13

High-throughput

0.479

High

616373

MBD5
Methyl-CpG-binding domain protein 5

1

3

High-throughput

0.479

High

616374

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

616342

TRM2A
tRNA

1

1

High-throughput

0.464

High

227363

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

616262

MSH2
DNA mismatch repair protein Msh2

1

0

High-throughput

0.458

High

616264

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

616289

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

616294

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

616307

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

616308

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

616324

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.458

High

616330

MIDN
Midnolin

1

0

High-throughput

0.458

High

616340

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

616345

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

616380

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

429275

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

616282

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

616362

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

156941

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

616254

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

616277

AFF1
AF4/FMR2 family member 1

1

5

High-throughput

0.437

High

616334

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.437

High

616348

MFRN2
Mitoferrin-2

1

1

High-throughput

0.437

High

616368

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

616375

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.437

High

442998

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

Small-scale

0.426

High

616270

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

155545

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.279

Low

616283

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.279

Low

350278

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.265

Low

421140

SCG1
Secretogranin-1

1

0

High-throughput

0.265

Low

616311

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.265

Low

616344

FAD1
FAD synthase

1

0

High-throughput

0.265

Low

352946

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

565137

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

616360

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

616336

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.238

Low

616326

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025