HitPredict

Interactor 1: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Interactor 2: SIR3 (P06701)
Regulatory protein SIR3 (Silent information regulator 3)
Gene: SIR3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.749

The method score is based on:

Property Details
Experiments 10219245, 15282295, 16543151, 17043313, 9122169, 15907466, 15899856, 18794362
Identification Methods affinity chromatography technology, pull down, biochemical, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0005677 - chromatin silencing complex
GO:0005730 - nucleolus
GO:0006303 - double-strand break repair via nonhomologous end joining
and 5 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 562
Sc

1 978
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024