HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: EDEM3 (Q9BZQ6)
ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)
Gene: EDEM3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29784879
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 932
+	Hs
		671915 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		EDEM3_HUMAN (1-932): 0: 1458: 100.00
+	Hs
		1310894 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		EDEM3_HUMAN (1-932): 0: 1458: 100.00
+	Hs
		531974 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		EDEM3_HUMAN (1-932): 0: 1458: 100.00
+	Hs
		1220461 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		EDEM3_HUMAN (1-932): 0: 1458: 100.00
+	Hs
		423344 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		EDEM2_HUMAN (19-535): 0: 618: 37.62
+	Hs
		423311 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		EDEM1_HUMAN (43-514): 0: 605: 42.42
+	Sc
		572779 PDI_YEAST (21-482): 4.03e-89: 284: 28.15		MNL1_YEAST (41-513): 0: 549: 35.28
+	Sc
		690739 EUG1_YEAST (2-508): 4.03e-84: 271: 21.46		MNL1_YEAST (41-513): 0: 549: 35.28
+	Hs
		1268001 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		EDEM1_HUMAN (43-514): 0: 605: 42.42
+	Hs
		531924 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		EDEM1_HUMAN (43-514): 0: 605: 42.42
+	Hs
		1220441 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		EDEM1_HUMAN (43-514): 0: 605: 42.42