Protein: ADA17
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)

Gene: ADA17, ADAM17
Organism: Homo sapiens
Interactions: 77
UniProt ID: P78536

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001666 - response to hypoxia
GO:0002446 - neutrophil mediated immunity
GO:0002467 - germinal center formation
GO:0002532 - production of molecular mediator involved in inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

774756

TIMP3
Metalloproteinase inhibitor 3

4

6

Small-scale

0.886

High

431785

ITB1
Integrin beta-1

2

14

Small-scale

0.768

High

168397

NCTR3
Natural cytotoxicity triggering receptor 3

1

3

High-throughput

0.691

High

1008426

DLG1
Disks large homolog 1

2

11

Small-scale

0.662

High

1008427

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

4

Small-scale

0.639

High

1008453

LMA2L
VIP36-like protein

3

0

High-throughput

0.634

High

1008433

SDK2
Protein sidekick-2

2

5

High-throughput

0.628

High

1008443

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

2

High-throughput

0.628

High

1008451

LRRC3
Leucine-rich repeat-containing protein 3

2

3

High-throughput

0.628

High

683986

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

4

Small-scale

0.626

High

1008459

FBX2
F-box only protein 2

2

12

High-throughput

0.601

High

630245

TNR1B
Tumor necrosis factor receptor superfamily member 1B

2

4

Small-scale

0.595

High

703533

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.589

High

1008455

FBX6
F-box only protein 6

2

12

High-throughput

0.584

High

1008463

INSL5
Insulin-like peptide INSL5

2

1

High-throughput

0.574

High

641937

CD9
CD9 antigen

2

20

Small-scale

0.570

High

341296

ECEL1
Endothelin-converting enzyme-like 1

1

3

High-throughput

0.536

High

563614

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

698579

CALX
Calnexin

1

17

High-throughput

0.536

High

717437

PDIA3
Protein disulfide-isomerase A3

1

5

Small-scale

0.536

High

845971

DCC
Netrin receptor DCC

1

6

High-throughput

0.536

High

1008428

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

5

High-throughput

0.536

High

1008444

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.536

High

1008446

T106A
Transmembrane protein 106A

1

7

High-throughput

0.536

High

1008454

SDF2L
Stromal cell-derived factor 2-like protein 1

1

7

High-throughput

0.536

High

193547

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

Small-scale

0.516

High

947976

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.513

High

1007859

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

622581

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.501

High

1008012

JAG1
Protein jagged-1

1

16

Small-scale

0.501

High

416606

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

880000

DNSL1
Deoxyribonuclease-1-like 1

1

2

High-throughput

0.489

High

1008432

EP3A
Epididymal secretory protein E3-alpha

1

1

High-throughput

0.489

High

1008445

CCL17
C-C motif chemokine 17

1

5

High-throughput

0.489

High

1008456

CAH10
Carbonic anhydrase-related protein 10

1

3

High-throughput

0.489

High

136872

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

13

High-throughput

0.479

High

218052

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

285211

EED
Polycomb protein EED

1

1

Small-scale

0.479

High

376603

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

2

Small-scale

0.479

High

556010

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

557224

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.479

High

691702

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

878433

PAXI
Paxillin

1

4

Small-scale

0.479

High

901180

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

1004440

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1008429

MTR1L
Melatonin-related receptor

1

2

Small-scale

0.479

High

1008430

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1008431

PTC1
Protein patched homolog 1

1

1

High-throughput

0.479

High

1008434

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1008435

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1008438

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1008439

SNX33
Sorting nexin-33

1

20

Small-scale

0.479

High

1008447

SNX18
Sorting nexin-18

1

19

Small-scale

0.479

High

1008450

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

19

Small-scale

0.479

High

1008452

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.479

High

1008460

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

20

Small-scale

0.479

High

1008461

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

1008462

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

19

Small-scale

0.479

High

1008464

SNX9
Sorting nexin-9

1

20

Small-scale

0.479

High

418062

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

903876

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

951096

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1008448

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1008449

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1008458

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

349403

TSN15
Tetraspanin-15

1

20

High-throughput

0.445

High

349626

TSN12
Tetraspanin-12

1

20

Small-scale

0.445

High

421910

A4
Amyloid-beta precursor protein

1

9

Small-scale

0.445

High

948783

CD81
CD81 antigen

1

20

High-throughput

0.445

High

967298

TSN5
Tetraspanin-5

1

20

High-throughput

0.445

High

1008436

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

4

High-throughput

0.445

High

1008440

CA054
Uncharacterized protein C1orf54

1

4

High-throughput

0.445

High

1008441

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

1008457

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.445

High

170726

CLGN
Calmegin

1

17

High-throughput

0.407

High

1008437

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

1008442

PATE1
Prostate and testis expressed protein 1

1

4

High-throughput

0.407

High


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Last updated: 11Aug2025