HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: FMNL2 (Q96PY5)
Formin-like protein 2 (Formin homology 2 domain-containing protein 2)
Gene: FMNL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031267 - small GTPase binding GO:0045296 - cadherin binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 1086
+	Hs
		430352 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		DIAP3_HUMAN (177-1072): 0: 605: 21.41
+	Hs
		430404 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		FHOD1_HUMAN (224-1079): 1.74e-151: 483: 15.51
+	Hs
		715022 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		FHOD1_HUMAN (224-1079): 1.74e-151: 483: 15.51
+	Hs
		314830 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		FMNL1_HUMAN (612-1083): 1.21e-130: 426: 56.99
+	Hs
		314847 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		FMNL1_HUMAN (612-1083): 1.21e-130: 426: 56.99
+	Hs
		243087 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		DIAP2_HUMAN (611-1073): 1.6e-119: 396: 20.84
+	Hs
		430356 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		FMN2_HUMAN (566-1036): 1.13e-87: 312: 20.40
+	Hs
		237549 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		DIAP1_HUMAN (97-651): 1.74e-55: 212: 17.38
+	Hs
		237564 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		DIAP1_HUMAN (97-651): 1.74e-55: 212: 17.38
+	Hs
		430197 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		INF2_HUMAN (224-368): 3.51e-16: 86.3: 33.56
+	Hs
		714970 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		INF2_HUMAN (224-368): 3.51e-16: 86.3: 33.56