HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 35271311, 34349018, 35235311
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~HATPase_c_3, HATPase_c_3~HSP90, HSP90~HSP90
Common GO terms GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005829 - cytosol
and 14 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 732
Hs

1 803
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Dm
+ At
+ Ce
+ Sp
+ Ca
+ Sc
+ Sc
+ Sc
+ Hs

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Last updated: 15 Jul 2024