HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: Q5TA56 (Q5TA56)
Argonaute RISC catalytic component 3 (Eukaryotic translation initiation factor 2C, 3, isoform CRA_a)
Gene: AGO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 229
+	Hs
		432271 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00
+	Hs
		432355 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO2_HUMAN (14-219): 1.71e-100: 311: 64.56
+	Hs
		438537 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00
+	Hs
		432356 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO1_HUMAN (9-219): 1.03e-99: 310: 69.19
+	Mm
		432448 HS90A_MOUSE (1-732): 0: 1083: 97.82		AGO2_MOUSE (4-219): 7.33e-101: 313: 62.04
+	Hs
		432278 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO4_HUMAN (3-219): 3.44e-96: 300: 66.36
+	Mm
		1174807 Q71LX8_MOUSE (19-732): 0: 1063: 86.98		AGO2_MOUSE (4-219): 7.33e-101: 313: 62.04
+	Hs
		438614 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO2_HUMAN (14-219): 1.71e-100: 311: 64.56
+	Hs
		438615 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO1_HUMAN (9-219): 1.03e-99: 310: 69.19
+	Hs
		438545 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO4_HUMAN (3-219): 3.44e-96: 300: 66.36
+	Dm
		365460 HSP83_DROME (15-732): 0: 1034: 78.41		Q32KD4_DROME (3-219): 4.18e-94: 297: 56.16
+	At
		138329 HS903_ARATH (15-732): 0: 981: 67.96		AGO1_ARATH (7-219): 2.11e-96: 304: 37.79
+	Dm
		365485 HSP83_DROME (15-732): 0: 1034: 78.41		AGO2_DROME (23-219): 8.55e-47: 167: 27.18
+	Hs
		1123461 H90B3_HUMAN (19-732): 0: 728: 65.41		AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00
+	Hs
		1123440 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00
+	Hs
		1123444 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO2_HUMAN (14-219): 1.71e-100: 311: 64.56
+	Hs
		1123445 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO1_HUMAN (9-219): 1.03e-99: 310: 69.19
+	Hs
		1123442 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO4_HUMAN (3-219): 3.44e-96: 300: 66.36
+	Dm
		1103835 Q9VAY2_DROME (15-700): 0: 537: 46.13		Q32KD4_DROME (3-219): 4.18e-94: 297: 56.16