Protein: VGFR2
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)

Gene: VGFR2, KDR
Organism: Homo sapiens
Interactions: 150
UniProt ID: P35968

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001541 - ovarian follicle development
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001934 - positive regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585441

VEGFA
Vascular endothelial growth factor A, long form

19

20

Small-scale

0.988

High

778028

VGFR2
Vascular endothelial growth factor receptor 2

7

16

Small-scale

0.958

High

164269

NRP1
Neuropilin-1

7

9

Small-scale

0.951

High

557143

SRC
Proto-oncogene tyrosine-protein kinase Src

6

20

Small-scale

0.937

High

711043

PTN6
Tyrosine-protein phosphatase non-receptor type 6

4

20

Small-scale

0.888

High

778051

SHC2
SHC-transforming protein 2

3

20

Small-scale

0.880

High

778037

VEGFC
Vascular endothelial growth factor C

2

20

Small-scale

0.845

High

778052

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

2

11

Small-scale

0.831

High

711261

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.830

High

777642

VGFR3
Vascular endothelial growth factor receptor 3

3

17

Small-scale

0.827

High

778055

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.826

High

778035

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

12

Small-scale

0.819

High

593930

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.789

High

609955

VGFR1
Vascular endothelial growth factor receptor 1

2

17

Small-scale

0.768

High

618999

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

18

Small-scale

0.755

High

778047

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.754

High

778058

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

Small-scale

0.730

High

778036

KC1D
Casein kinase I isoform delta

1

2

Small-scale

0.724

High

778054

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.698

High

778069

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

778044

1433G
14-3-3 protein gamma

1

14

High-throughput

0.691

High

778070

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.691

High

778087

PALLD
Palladin

1

20

High-throughput

0.691

High

778104

SH22A
SH2 domain-containing protein 2A

1

20

Small-scale

0.681

High

231038

VEGFD
Vascular endothelial growth factor D

1

20

Small-scale

0.647

High

657213

KALM
Anosmin-1

1

13

Small-scale

0.647

High

703463

MK01
Mitogen-activated protein kinase 1

1

9

Small-scale

0.647

High

749753

CADH5
Cadherin-5

3

9

Small-scale

0.643

High

421612

A4
Amyloid-beta precursor protein

2

5

Small-scale

0.629

High

778061

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.621

High

440416

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

461214

HS90A
Heat shock protein HSP 90-alpha

1

18

Small-scale

0.618

High

472008

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.618

High

484067

PGFRB
Platelet-derived growth factor receptor beta

1

18

Small-scale

0.618

High

631090

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.618

High

635681

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.618

High

778032

STAT3
Signal transducer and activator of transcription 3

1

13

Small-scale

0.618

High

778033

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

13

Small-scale

0.618

High

778039

DYN2
Dynamin-2

1

10

Small-scale

0.618

High

778067

LRP8
Low-density lipoprotein receptor-related protein 8

1

5

Small-scale

0.618

High

778112

PLXA1
Plexin-A1

1

14

Small-scale

0.618

High

778118

PLXD1
Plexin-D1

1

16

Small-scale

0.618

High

778113

FBW1B
F-box/WD repeat-containing protein 11

2

8

Small-scale

0.600

High

651191

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.595

High

778116

FBW1A
F-box/WD repeat-containing protein 1A

2

8

Small-scale

0.590

High

251678

GREM1
Gremlin-1

1

2

Small-scale

0.578

High

480731

LEG1
Galectin-1

1

8

Small-scale

0.578

High

431733

ITB1
Integrin beta-1

2

8

Small-scale

0.571

High

327835

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

Small-scale

0.552

High

290878

PPM1B
Protein phosphatase 1B

1

6

High-throughput

0.541

High

776934

PPM1A
Protein phosphatase 1A

1

6

High-throughput

0.541

High

778085

DUS19
Dual specificity protein phosphatase 19

1

13

High-throughput

0.541

High

778086

STYX
Serine/threonine/tyrosine-interacting protein

1

13

High-throughput

0.541

High

276437

PDCD6
Programmed cell death protein 6

1

2

Small-scale

0.529

High

476104

ANXA5
Annexin A5

1

1

Small-scale

0.527

High

532410

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.515

High

680248

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

High-throughput

0.515

High

225183

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.513

High

778076

NNRD
ATP-dependent

1

0

High-throughput

0.513

High

778060

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.508

High

778029

PEDF
Pigment epithelium-derived factor

1

7

Small-scale

0.501

High

778031

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

2

Small-scale

0.501

High

778071

GRDN
Girdin

1

13

Small-scale

0.501

High

778082

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

778089

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.501

High

778101

PDCL3
Phosducin-like protein 3

1

2

Small-scale

0.501

High

778100

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

12

High-throughput

0.494

High

778030

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

243559

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

7

High-throughput

0.479

High

277581

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.479

High

424016

ITB3
Integrin beta-3

1

12

Small-scale

0.479

High

452187

PDIA1
Protein disulfide-isomerase

1

12

Small-scale

0.479

High

473668

ITA5
Integrin alpha-5

1

6

Small-scale

0.479

High

507614

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

603755

ITA2
Integrin alpha-2

1

6

Small-scale

0.479

High

613311

VINC
Vinculin

1

5

Small-scale

0.479

High

703275

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

7

High-throughput

0.479

High

748671

IL3RB
Cytokine receptor common subunit beta

1

9

Small-scale

0.479

High

778034

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.479

High

778038

EMD
Emerin

1

6

High-throughput

0.479

High

778040

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

6

Small-scale

0.479

High

778041

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

Small-scale

0.479

High

778042

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

High-throughput

0.479

High

778043

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.479

High

778045

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

2

High-throughput

0.479

High

778046

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

Small-scale

0.479

High

778048

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.479

High

778053

ATP7A
Copper-transporting ATPase 1

1

1

Small-scale

0.479

High

778057

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

5

High-throughput

0.479

High

778062

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

778063

TRA2A
Transformer-2 protein homolog alpha

1

2

High-throughput

0.479

High

778064

PWP1
Periodic tryptophan protein 1 homolog

1

8

High-throughput

0.479

High

778065

CUL1
Cullin-1

1

4

Small-scale

0.479

High

778066

NCOA4
Nuclear receptor coactivator 4

1

1

High-throughput

0.479

High

778068

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.479

High

778074

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.479

High

778075

AHNK2
Protein AHNAK2

1

3

High-throughput

0.479

High

778077

GCC2
GRIP and coiled-coil domain-containing protein 2

1

6

High-throughput

0.479

High

778078

PHF6
PHD finger protein 6

1

5

High-throughput

0.479

High

778081

ZN397
Zinc finger protein 397

1

3

High-throughput

0.479

High

778083

DDX54
ATP-dependent RNA helicase DDX54

1

14

High-throughput

0.479

High

778084

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

6

High-throughput

0.479

High

778090

TNR25
Tumor necrosis factor receptor superfamily member 25

1

12

Small-scale

0.479

High

778092

DDX27
Probable ATP-dependent RNA helicase DDX27

1

14

High-throughput

0.479

High

778093

ZFP3
Zinc finger protein 3 homolog

1

1

High-throughput

0.479

High

778094

RBM14
RNA-binding protein 14

1

7

High-throughput

0.479

High

778095

RBM15
RNA-binding protein 15

1

3

High-throughput

0.479

High

778096

MINT
Msx2-interacting protein

1

3

High-throughput

0.479

High

778099

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

778105

SCUB2
Signal peptide, CUB and EGF-like domain-containing protein 2

1

5

Small-scale

0.479

High

778106

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

12

High-throughput

0.479

High

778107

MDN1
Midasin

1

8

High-throughput

0.479

High

778108

SEC63
Translocation protein SEC63 homolog

1

13

High-throughput

0.479

High

778110

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

17

High-throughput

0.479

High

778111

BAZ1B
Tyrosine-protein kinase BAZ1B

1

9

High-throughput

0.479

High

778114

RALY
RNA-binding protein Raly

1

1

High-throughput

0.479

High

778115

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

3

High-throughput

0.479

High

778119

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

3

High-throughput

0.479

High

778120

SP16H
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

778121

EPN1
Epsin-1

1

11

Small-scale

0.479

High

446712

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

542356

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

621569

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

108020

G3V1M0
Uncharacterized protein DKFZp686H10254

1

5

High-throughput

0.445

High

778050

HTRA4
Serine protease HTRA4

1

4

Small-scale

0.445

High

778059

GNDS
Ral guanine nucleotide dissociation stimulator

1

3

Small-scale

0.445

High

778103

ANTR1
Anthrax toxin receptor 1

1

5

Small-scale

0.445

High

291233

NU155
Nuclear pore complex protein Nup155

1

6

High-throughput

0.437

High

483527

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

5

High-throughput

0.437

High

615337

SON
Protein SON

1

5

High-throughput

0.437

High

627603

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

5

High-throughput

0.437

High

778049

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.437

High

778073

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.437

High

778080

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.437

High

778088

NU205
Nuclear pore complex protein Nup205

1

7

High-throughput

0.437

High

778097

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.437

High

778098

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.437

High

778102

TXNIP
Thioredoxin-interacting protein

1

5

Small-scale

0.437

High

778109

IPO11
Importin-11

1

3

High-throughput

0.437

High

778117

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

58640

A2A2Q9
Protein AAR2 homolog

1

2

High-throughput

0.407

High

76173

B4DF87
Nuclear receptor coactivator 4

1

1

High-throughput

0.407

High

142492

IMA3
Importin subunit alpha-3

1

0

High-throughput

0.391

High

778072

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.279

Low

778056

QOR
Quinone oxidoreductase

1

0

High-throughput

0.261

Low

666075

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

Small-scale

0.251

Low

272890

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.249

Low

778079

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.249

Low

778091

MSI2H
RNA-binding protein Musashi homolog 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025