HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: LIMK1 (P53667)
LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)
Gene: LIMK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0031072 - heat shock protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 647
+	Hs
		438023 HS90B_HUMAN (1-724): 0: 1086: 100.00		LIMK2_HUMAN (18-640): 9.61e-175: 513: 52.80
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (6-641): 8.54e-143: 442: 17.90
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (14-630): 2.75e-137: 427: 18.20
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (14-644): 4.34e-131: 411: 17.93
+	Hs
		437860 HS90B_HUMAN (1-724): 0: 1086: 100.00		BRAF_HUMAN (83-645): 2.36e-128: 398: 21.29
+	Hs
		431561 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA2_HUMAN (14-644): 4.34e-131: 411: 17.93
+	Hs
		431496 HS90A_HUMAN (1-724): 0: 1072: 85.25		BRAF_HUMAN (83-645): 2.36e-128: 398: 21.29
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (253-647): 3.13e-113: 360: 23.77
+	Hs
		373549 HS90B_HUMAN (1-724): 0: 1086: 100.00		RAF1_HUMAN (83-613): 2.71e-110: 347: 19.41
+	Hs
		431472 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR1_HUMAN (253-647): 3.13e-113: 360: 23.77
+	Hs
		437832 HS90B_HUMAN (1-724): 0: 1086: 100.00		ARAF_HUMAN (83-613): 2.71e-110: 346: 22.26
+	Hs
		437897 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR3_HUMAN (267-646): 4.34e-108: 346: 23.23
+	Hs
		373543 HS90A_HUMAN (1-724): 0: 1072: 85.25		RAF1_HUMAN (83-613): 2.71e-110: 347: 19.41
+	Hs
		431459 HS90A_HUMAN (1-724): 0: 1072: 85.25		ARAF_HUMAN (83-613): 2.71e-110: 346: 22.26
+	Hs
		431536 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR3_HUMAN (267-646): 4.34e-108: 346: 23.23
+	Hs
		437867 HS90B_HUMAN (1-724): 0: 1086: 100.00		FER_HUMAN (326-611): 1.02e-97: 319: 31.12
+	Hs
		431507 HS90A_HUMAN (1-724): 0: 1072: 85.25		FER_HUMAN (326-611): 1.02e-97: 319: 31.12
+	Hs
		438454 HS90B_HUMAN (1-724): 0: 1086: 100.00		TESK2_HUMAN (343-607): 6.3e-66: 228: 44.40
+	Hs
		438195 HS90B_HUMAN (1-724): 0: 1086: 100.00		TESK1_HUMAN (335-617): 1.14e-60: 215: 43.71
+	Hs
		437967 HS90B_HUMAN (1-724): 0: 1086: 100.00		FRK_HUMAN (345-606): 3.26e-31: 129: 33.94