HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: MYLK2 (Q9H1R3)
Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
Gene: MYLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	31980649, unassigned2173, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 596
+	Hs
		438224 HS90B_HUMAN (1-724): 0: 1086: 100.00		MYLK3_HUMAN (10-588): 3.51e-137: 420: 42.81
+	Hs
		438328 HS90B_HUMAN (1-724): 0: 1086: 100.00		MYLK4_HUMAN (219-562): 3.06e-140: 414: 53.20
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (172-594): 1.37e-136: 408: 21.09
+	Hs
		431913 HS90A_HUMAN (1-724): 0: 1072: 85.25		MYLK3_HUMAN (10-588): 3.51e-137: 420: 42.81
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (172-588): 1.13e-134: 403: 21.43
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (172-588): 1.09e-135: 405: 21.20
+	Hs
		438631 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC2A_HUMAN (271-596): 2.76e-134: 402: 32.33
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (153-591): 6.27e-134: 401: 19.96
+	Hs
		432028 HS90A_HUMAN (1-724): 0: 1072: 85.25		MYLK4_HUMAN (219-562): 3.06e-140: 414: 53.20
+	Hs
		438148 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (275-586): 4.3e-133: 399: 30.03
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (172-594): 1.37e-136: 408: 21.09
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (172-588): 3.1e-135: 404: 21.43
+	Hs
		431827 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC2D_HUMAN (280-596): 5.43e-133: 399: 30.53
+	Hs
		200083 HS90B_HUMAN (1-724): 0: 1086: 100.00		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		431682 HS90A_HUMAN (1-724): 0: 1072: 85.25		DAPK1_HUMAN (271-540): 5.04e-64: 230: 42.09
+	Hs
		200082 HS90A_HUMAN (1-724): 0: 1072: 85.25		DAPK3_HUMAN (271-566): 4.44e-67: 227: 40.06
+	Hs
		437842 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPSH1_HUMAN (261-562): 2.14e-48: 176: 34.95
+	Hs
		431475 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPSH1_HUMAN (261-562): 2.14e-48: 176: 34.95