HitPredict

Interactor 1: ODPA (P08559)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
Gene: PDHA1

Interactor 2: PREP (Q5JRX3)
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)
Gene: PITRM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 390 Hs			1 1037
+	Hs
		1127421 OGDHL_HUMAN (5-366): 9.61e-123: 380: 13.10		PREP_HUMAN (1-1037): 0: 949: 100.00
+	Sc
		558597 ODPA_YEAST (42-383): 1.18e-149: 431: 52.01		PREP_YEAST (24-1037): 0: 629: 35.24
+	Zm
		73712 B4F923_MAIZE (2-388): 5.75e-148: 429: 28.00		K7VZS5_MAIZE (66-1036): 2.22e-163: 510: 11.57
+	Dm
		1214905 Q8IQQ0_DROME (8-385): 6.23e-124: 383: 15.14		Q9VYT3_DROME (79-1022): 1.11e-155: 493: 12.58
+	Hs
		264814 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		MPPB_HUMAN (8-505): 1.59e-100: 326: 14.43
+	Hs
		440487 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		MPPA_HUMAN (2-502): 7.65e-98: 321: 11.58
+	Hs
		440366 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		QCR1_HUMAN (60-517): 4.81e-89: 295: 12.50
+	Sc
		489664 ODPA_YEAST (42-383): 1.18e-149: 431: 52.01		MPPB_YEAST (51-504): 1.05e-90: 299: 13.68
+	Hs
		264824 ODBA_HUMAN (3-386): 4.22e-134: 392: 24.17		MPPB_HUMAN (8-505): 1.59e-100: 326: 14.43
+	Hs
		264893 ODO1_HUMAN (2-366): 2.85e-125: 387: 14.75		MPPB_HUMAN (8-505): 1.59e-100: 326: 14.43
+	Hs
		969471 ODO1_HUMAN (2-366): 2.85e-125: 387: 14.75		MPPA_HUMAN (2-502): 7.65e-98: 321: 11.58
+	Hs
		265078 OGDHL_HUMAN (5-366): 9.61e-123: 380: 13.10		MPPB_HUMAN (8-505): 1.59e-100: 326: 14.43