HitPredict

Interactor 1: RPB1 (P08775)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: Polr2a

Interactor 2: SMCA4 (Q3TKT4)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: Smarca4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15999204
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000791 - euchromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006366 - transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1970 Mm			1 1613
+	Hs
		624816 RPB1_HUMAN (1-1611): 0: 1886: 100.00		SMCA4_HUMAN (1-1613): 0: 1071: 97.21
+	Hs
		624815 RPB1_HUMAN (1-1611): 0: 1886: 100.00		SMCA2_HUMAN (40-1613): 0: 989: 74.00
+	Hs
		625053 RPB1_HUMAN (1-1611): 0: 1886: 100.00		CHD8_HUMAN (13-1454): 0: 712: 21.06
+	Sc
		375326 RPB1_YEAST (11-1606): 0: 1604: 49.35		STH1_YEAST (1210-1529): 7.97e-23: 108: 13.80
+	Sc
		375591 RPC1_YEAST (11-1471): 0: 1343: 32.62		STH1_YEAST (1210-1529): 7.97e-23: 108: 13.80
+	Sc
		501341 RPA1_YEAST (11-1471): 0: 1126: 23.05		STH1_YEAST (1210-1529): 7.97e-23: 108: 13.80
+	Hs
		229264 RPA1_HUMAN (960-1476): 2.71e-45: 183: 16.39		SMCA5_HUMAN (596-1579): 0: 795: 27.82
+	Dm
		375643 RPB1_DROME (1569-1970): 2.84e-18: 94.2: 42.17		BRM_DROME (53-1603): 0: 823: 49.38
+	Dm
		332845 Q9VGW4_DROME (1597-1940): 1.78e-10: 68.8: 29.07		CHDM_DROME (423-1605): 0: 693: 23.67