HitPredict

Interactor 1: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Interactor 2: CROCC (Q5TZA2)
Rootletin (Ciliary rootlet coiled-coil protein)
Gene: CROCC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 285 Hs			1 2017
+	Hs
		482912 TPM1_HUMAN (2-285): 1.36e-44: 154: 91.20		CROCC_HUMAN (1-2017): 1.44e-144: 499: 100.00
+	Hs
		1216691 EP15R_HUMAN (155-285): 8.49e-10: 61.1: 20.61		CROCC_HUMAN (1-2017): 1.44e-144: 499: 100.00
+	Dm
		883981 TPM4_DROME (2-282): 1.38e-34: 132: 56.23		Q9VCD1_DROME (556-2017): 1.74e-42: 173: 12.54
+	Hs
		447692 TPM3_HUMAN (1-285): 1.29e-44: 154: 100.00		MYH9_HUMAN (1-607): 9.28e-21: 102: 11.51
+	Hs
		482842 TPM1_HUMAN (2-285): 1.36e-44: 154: 91.20		MYH9_HUMAN (1-607): 9.28e-21: 102: 11.51
+	Hs
		464124 TPM2_HUMAN (2-285): 1.41e-40: 143: 86.27		MYH9_HUMAN (1-607): 9.28e-21: 102: 11.51
+	Hs
		116462 H7BYY1_HUMAN (41-285): 5.71e-36: 130: 64.90		MYH9_HUMAN (1-607): 9.28e-21: 102: 11.51
+	Hs
		772732 TPM4_HUMAN (43-285): 3.76e-34: 126: 69.96		MYH9_HUMAN (1-607): 9.28e-21: 102: 11.51
+	Hs
		156848 TPM3_HUMAN (1-285): 1.29e-44: 154: 100.00		CTRO_HUMAN (546-1275): 5.63e-09: 63.9: 21.01
+	Hs
		995421 TPM4_HUMAN (43-285): 3.76e-34: 126: 69.96		EEA1_HUMAN (1-446): 5.85e-15: 83.4: 8.89
+	Hs
		937397 LAMB2_HUMAN (8-285): 1.26e-29: 120: 14.24		EEA1_HUMAN (1-446): 5.85e-15: 83.4: 8.89
+	Hs
		157221 TPM4_HUMAN (43-285): 3.76e-34: 126: 69.96		CTRO_HUMAN (546-1275): 5.63e-09: 63.9: 21.01