HitPredict

Interactor 1: GRPE (P09372)
Protein GrpE (HSP-70 cofactor) (HSP24) (Heat shock protein B25.3)
Gene: GRPE

Interactor 2: DNAK (P0A6Y8)
Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70)
Gene: DNAK

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

The method score is based on:

Property	Details
Experiments	16606699, 9103205, 15690043
Identification Methods	affinity chromatography technology, x-ray crystallography, surface plasmon resonance, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	GrpE~HSP70
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009408 - response to heat GO:0032991 - protein-containing complex GO:0043335 - protein unfolding and 4 others more... GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding GO:0051087 - protein-folding chaperone binding GO:0065003 - protein-containing complex assembly
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	197
Ec

1	638

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024