HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 582
+	Hs
		643353 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		175780 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		996697 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		818109 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		567710 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		958925 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		516365 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		403201 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		403120 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		818011 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Mm
		857305 HMGB1_MOUSE (1-174): 9.92e-46: 152: 100.00		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		449749 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		403191 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Sc
		376710 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Hs
		818520 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Hs
		567762 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		996687 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		818170 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		959069 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Hs
		1162653 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23