HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: H2A2A (Q6FI13)
Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)
Gene: H2AC18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 130
+	Hs
		449762 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		H2A2B_HUMAN (1-130): 1.54e-65: 196: 94.62
+	Hs
		643357 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		643395 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		H2A1J_HUMAN (1-128): 2.76e-66: 198: 97.66
+	Hs
		996711 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		391670 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470362 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		996730 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A3_HUMAN (1-130): 6.2e-67: 199: 97.69
+	Hs
		996856 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A1J_HUMAN (1-128): 2.76e-66: 198: 97.66
+	Hs
		996754 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A2B_HUMAN (1-130): 1.54e-65: 196: 94.62
+	Hs
		996693 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88
+	Hs
		996868 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2AJ_HUMAN (1-128): 2.61e-64: 193: 94.53
+	Hs
		555429 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		594829 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		H2A1D_HUMAN (1-130): 7.72e-67: 199: 97.69
+	Hs
		391917 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Sc
		392263 NHP6A_YEAST (75-164): 2.33e-23: 91.4: 45.56		H2A2_YEAST (16-128): 5.91e-59: 179: 80.53
+	Sc
		392264 NHP6B_YEAST (73-164): 1.14e-21: 87.1: 42.39		H2A2_YEAST (16-128): 5.91e-59: 179: 80.53
+	Sc
		392030 NHP6A_YEAST (75-164): 2.33e-23: 91.4: 45.56		H2A1_YEAST (16-127): 2.97e-53: 165: 81.25
+	Sc
		392374 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		H2A2_YEAST (16-128): 5.91e-59: 179: 80.53
+	Sc
		392031 NHP6B_YEAST (73-164): 1.14e-21: 87.1: 42.39		H2A1_YEAST (16-127): 2.97e-53: 165: 81.25
+	Ce
		136713 SSP1B_CAEEL (91-208): 5.6e-18: 83.7: 32.80		Q27485_CAEEL (17-121): 1.89e-54: 168: 90.48