HitPredict

Interactor 1: CLCB (P09497)
Clathrin light chain B (Lcb)
Gene: CLTB

Interactor 2: AP2S1 (P53680)
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: AP2S1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0043231 - intracellular membrane-bounded organelle GO:0045334 - clathrin-coated endocytic vesicle and 1 others more... GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 142
+	Hs
		451407 CLCA_HUMAN (13-227): 2.26e-100: 293: 61.23		AP1S2_HUMAN (2-142): 5.11e-51: 161: 46.10
+	Hs
		451409 CLCA_HUMAN (13-227): 2.26e-100: 293: 61.23		AP1S1_HUMAN (1-142): 2.51e-51: 161: 44.37
+	Hs
		451547 CLCA_HUMAN (13-227): 2.26e-100: 293: 61.23		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		451400 CLCA_HUMAN (13-227): 2.26e-100: 293: 61.23		AP2S1_HUMAN (1-142): 6.18e-46: 147: 100.00
+	Hs
		451529 CLCA_HUMAN (13-227): 2.26e-100: 293: 61.23		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22
+	Hs
		451725 CLCB_HUMAN (1-229): 2.06e-95: 279: 100.00		AP1M1_HUMAN (2-137): 4.68e-44: 150: 14.71
+	Hs
		451718 CLCB_HUMAN (1-229): 2.06e-95: 279: 100.00		AP2M1_HUMAN (1-138): 1.82e-41: 144: 15.22