HitPredict

Interactor 1: HMGA2 (P52926)
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)
Gene: HMGA2

Interactor 2: SMAD5 (Q99717)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)
Gene: SMAD5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18425117
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043066 - negative regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0071141 - SMAD protein complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 109 Hs			1 465
+	Hs
		857473 HMGA2_HUMAN (1-109): 6.26e-43: 137: 100.00		SMAD1_HUMAN (3-465): 0: 637: 89.68
+	Hs
		171376 HMGA2_HUMAN (1-109): 6.26e-43: 137: 100.00		SMAD9_HUMAN (2-465): 0: 617: 78.54
+	Mm
		857640 HMGA2_MOUSE (1-109): 4.6e-41: 133: 95.41		SMAD2_MOUSE (4-465): 0: 532: 55.60