Protein: KI2L3
Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)

Gene: KI2L3, KIR2DL3
Organism: Homo sapiens
Interactions: 82
UniProt ID: P43628

Gene Ontology (top 5):
GO:0002764 - immune response-regulating signaling pathway
GO:0003823 - antigen binding
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520777

HLAC
HLA class I histocompatibility antigen, C alpha chain

4

20

Small-scale

0.901

High

850813

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

14

High-throughput

0.783

High

850845

BT2A2
Butyrophilin subfamily 2 member A2

2

3

High-throughput

0.783

High

850820

Q53YP1
HLA class I histocompatibility antigen C alpha chain

2

20

Small-scale

0.778

High

711056

PTN6
Tyrosine-protein phosphatase non-receptor type 6

4

20

Small-scale

0.687

High

3746

A0A142JA41
HLA-C alpha chain for Cw*18GB

1

20

Small-scale

0.647

High

47048

A0A583ZBW7
HLA-C protein

1

20

Small-scale

0.647

High

91506

C9E8W1
HLA-C alpha chain

1

20

Small-scale

0.647

High

92146

D2IYK1
HLA class I histocompatibility antigen B alpha chain

1

20

Small-scale

0.647

High

379933

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

20

Small-scale

0.647

High

850823

Q5D1W8
HLA class I histocompatibility antigen C alpha chain

1

20

Small-scale

0.647

High

850826

Q5QT33
HLA class I antigen

1

20

Small-scale

0.647

High

850827

Q5RIP0
HLA class I histocompatibility antigen C alpha chain

1

20

Small-scale

0.647

High

850828

Q5S3G3
HLA class I histocompatibility antigen A alpha chain

1

20

Small-scale

0.647

High

850833

Q7YNW6
HLA class I histocompatibility antigen C alpha chain

1

20

Small-scale

0.647

High

850834

Q7YQB1
MHC class I antigen

1

20

Small-scale

0.647

High

850862

V6DZ76
MHC class I antigen

1

20

Small-scale

0.647

High

139192

UPK2
Uroplakin-2

2

2

High-throughput

0.606

High

208975

CYB5B
Cytochrome b5 type B

2

4

High-throughput

0.606

High

220360

LAT
Linker for activation of T-cells family member 1

2

1

High-throughput

0.606

High

295674

UPK1B
Uroplakin-1b

2

4

High-throughput

0.606

High

328642

VAMP5
Vesicle-associated membrane protein 5

2

3

High-throughput

0.606

High

451654

TRBM
Thrombomodulin

2

7

High-throughput

0.606

High

455905

ASGR1
Asialoglycoprotein receptor 1

2

3

High-throughput

0.606

High

539461

ITAM
Integrin alpha-M

2

6

High-throughput

0.606

High

850814

CXA8
Gap junction alpha-8 protein

2

2

High-throughput

0.606

High

850815

EMD
Emerin

2

1

High-throughput

0.606

High

850821

SGMR2
Sigma intracellular receptor 2

2

1

High-throughput

0.606

High

850822

TTMP
TPA-induced transmembrane protein

2

1

High-throughput

0.606

High

850830

ATRAP
Type-1 angiotensin II receptor-associated protein

2

1

High-throughput

0.606

High

850831

OLFM4
Olfactomedin-4

2

1

High-throughput

0.606

High

850835

KTN1
Kinectin

2

1

High-throughput

0.606

High

850836

ANR46
Ankyrin repeat domain-containing protein 46

2

6

High-throughput

0.606

High

850838

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

2

High-throughput

0.606

High

850841

CLD19
Claudin-19

2

3

High-throughput

0.606

High

850843

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

1

High-throughput

0.606

High

850844

GPX8
Probable glutathione peroxidase 8

2

2

High-throughput

0.606

High

850847

PLPR2
Phospholipid phosphatase-related protein type 2

2

1

High-throughput

0.606

High

850858

NINJ2
Ninjurin-2

2

2

High-throughput

0.606

High

850859

AGRE2
Adhesion G protein-coupled receptor E2

2

3

High-throughput

0.606

High

850860

T3JAM
TRAF3-interacting JNK-activating modulator

2

3

High-throughput

0.606

High

60560

TM218
Transmembrane protein 218

2

0

High-throughput

0.580

High

74155

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

162171

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

688376

PPLA
Phospholamban

2

0

High-throughput

0.580

High

843328

NSG1
Neuronal vesicle trafficking-associated protein 1

2

0

High-throughput

0.580

High

850816

IFM3
Interferon-induced transmembrane protein 3

2

0

High-throughput

0.580

High

850818

CXCL9
C-X-C motif chemokine 9

2

0

High-throughput

0.580

High

850825

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.580

High

850829

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.580

High

850832

SNORC
Protein SNORC

2

0

High-throughput

0.580

High

850837

NRM
Nurim

2

0

High-throughput

0.580

High

850840

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.580

High

850848

AQP10
Aquaporin-10

2

0

High-throughput

0.580

High

850850

TM243
Transmembrane protein 243

2

0

High-throughput

0.580

High

850852

TM222
Transmembrane protein 222

2

0

High-throughput

0.580

High

850854

GP108
Protein GPR108

2

0

High-throughput

0.580

High

850855

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.580

High

850856

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.580

High

850857

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

High-throughput

0.580

High

71840

LEUTX
Paired-like homeodomain transcription factor LEUTX

2

1

High-throughput

0.553

High

274989

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

1

High-throughput

0.553

High

280148

SC22B
Vesicle-trafficking protein SEC22b

2

2

High-throughput

0.553

High

335542

BMP10
Bone morphogenetic protein 10

2

2

High-throughput

0.553

High

423747

APOD
Apolipoprotein D

2

3

High-throughput

0.553

High

850824

F209A
Protein FAM209A

2

1

High-throughput

0.553

High

850839

JAGN1
Protein jagunal homolog 1

2

3

High-throughput

0.553

High

850842

RN152
E3 ubiquitin-protein ligase RNF152

2

2

High-throughput

0.553

High

850846

FAM3C
Protein FAM3C

2

2

High-throughput

0.553

High

421676

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

230945

TYOBP
TYRO protein tyrosine kinase-binding protein

1

3

Small-scale

0.479

High

850853

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

850817

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.442

High

612921

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

850819

RUNX3
Runt-related transcription factor 3

1

3

Small-scale

0.437

High

186468

VA0E1
V-type proton ATPase subunit e 1

2

0

High-throughput

0.316

High

377849

GAST
Gastrin [Cleaved into: Gastrin-71

2

0

High-throughput

0.316

High

387513

APOA2
Apolipoprotein A-II

2

0

High-throughput

0.316

High

850849

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.316

High

850851

FUND2
FUN14 domain-containing protein 2

2

0

High-throughput

0.316

High

850861

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025