HitPredict

Interactor 1: INHBB (P09529)
Inhibin beta B chain (Activin beta-B chain)
Gene: INHBB

Interactor 2: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	28126904, 9202237, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0007283 - spermatogenesis GO:0032924 - activin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 407 Hs			1 513
+	Hs
		451820 INHBB_HUMAN (1-407): 4.22e-149: 430: 100.00		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		451821 INHBB_HUMAN (1-407): 4.22e-149: 430: 100.00		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		520070 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		451818 INHBB_HUMAN (1-407): 4.22e-149: 430: 100.00		ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41
+	Mm
		646088 INHBA_MOUSE (43-407): 2.67e-106: 321: 42.26		AVR2A_MOUSE (1-513): 1.26e-154: 452: 99.61
+	Hs
		439881 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		574181 BMP7_HUMAN (67-406): 4.61e-98: 301: 21.52		AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00
+	Hs
		520077 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		439886 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		59851 A4D1W7_HUMAN (43-407): 3.12e-104: 316: 41.57		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Mm
		646092 INHBA_MOUSE (43-407): 2.67e-106: 321: 42.26		AVR2B_MOUSE (4-513): 1.8e-137: 409: 64.42
+	Hs
		122280 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		BMR1B_HUMAN (59-488): 2.3e-130: 390: 33.55
+	Hs
		520071 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41
+	Hs
		520078 BMP2_HUMAN (49-406): 4.94e-109: 327: 23.70		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		122282 BMP7_HUMAN (67-406): 4.61e-98: 301: 21.52		BMR1B_HUMAN (59-488): 2.3e-130: 390: 33.55
+	Hs
		439887 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Hs
		439885 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		ACVR1_HUMAN (47-493): 6.71e-117: 355: 30.27
+	Mm
		982854 INHBA_MOUSE (43-407): 2.67e-106: 321: 42.26		ACV1B_MOUSE (2-488): 1.87e-112: 344: 28.22
+	Hs
		439882 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41
+	Hs
		439883 INHBA_HUMAN (43-407): 3.12e-104: 316: 41.57		ACVL1_HUMAN (42-490): 2.89e-106: 328: 29.38